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Journal article
Neural Interactions in Developing Rhythmogenic Spinal Networks: Insights From Computational Modeling
Frontiers in neural circuits, v 14, pp 614615-614615
23 Dec 2020
PMID: 33424558
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The mechanisms involved in generation of rhythmic locomotor activity in the mammalian spinal cord remain poorly understood. These mechanisms supposedly rely on both intrinsic properties of constituting neurons and interactions between them. A subset of Shox2 neurons was suggested to contribute to generation of spinal locomotor activity, but the possible cellular basis for rhythmic bursting in these neurons remains unknown. Ha and Dougherty (
2018
) recently revealed the presence of bidirectional electrical coupling between Shox2 neurons in neonatal spinal cords, which can be critically involved in neuronal synchronization and generation of populational bursting. Gap junctional connections found between functionally-related Shox2 interneurons decrease with age, possibly being replaced by increasing interactions through chemical synapses. Here, we developed a computational model of a heterogeneous population of neurons sparsely connected by electrical or/and chemical synapses and investigated the dependence of frequency of populational bursting on the type and strength of neuronal interconnections. The model proposes a mechanistic explanation that can account for the emergence of a synchronized rhythmic activity in the neuronal population and provides insights into the possible role of gap junctional coupling between Shox2 neurons in the spinal mechanisms for locomotor rhythm generation.
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Details
- Title
- Neural Interactions in Developing Rhythmogenic Spinal Networks: Insights From Computational Modeling
- Creators
- Natalia A. Shevtsova - Drexel UniversityNgoc T. Ha - Drexel UniversityIlya A. Rybak - Drexel UniversityKimberly J. Dougherty - Drexel University
- Publication Details
- Frontiers in neural circuits, v 14, pp 614615-614615
- Publisher
- Frontiers Media S.A
- Grant note
- R01 NS090919; R01 NS095366; R01 NS100928; R01 NS110550 / National Institute of Neurological Disorders and Stroke
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000605961000001
- Scopus ID
- 2-s2.0-85099119439
- Other Identifier
- 991019168067004721
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- Web of Science research areas
- Neurosciences