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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Neural Progenitor Cells Grown on Hydrogel Surfaces Respond to the product of the Transgene of Encapsulated Genetically Engineered Fibroblasts
Biomacromolecules, v 11(11), pp 2936-2943
13 Oct 2010
PMID: 20942395
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Engineered tissue strategies for central nervous system (CNS) repair have the potential for localizing treatment using a wide variety of cells or growth factors. However, these strategies are often limited by their ability to address only one aspect of the injury. Here we report the development of a novel alginate construct that acts as a multi-functional tissue scaffold for CNS repair, and as a localized growth factor delivery vehicle. We show that the surface of this alginate construct acts as an optimal growth environment for neural progenitor cell (NPC) attachment, survival, migration, and differentiation. Importantly, we show that tailor-made alginate constructs containing brain-derived neurotrophic factor or neurotrophin-3 differentially direct lineage fates of NPCs and may therefore be useful in treating a wide variety of injuries. It is this potential for directed differentiation of a scaffold prior to implantation at the injury site that we explore here.
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Details
- Title
- Neural Progenitor Cells Grown on Hydrogel Surfaces Respond to the product of the Transgene of Encapsulated Genetically Engineered Fibroblasts
- Creators
- Mihir S. Shanbhag - University of CambridgeJustin D. Lathia - University of CambridgeMohamed R. Mughal - University of EdinburghNicola L. Francis - Drexel UniversityNicholas Pashos - Drexel UniversityMark P. Mattson - University of CambridgeMargaret A. Wheatley - Drexel University
- Publication Details
- Biomacromolecules, v 11(11), pp 2936-2943
- Publisher
- American Chemical Society; Washington, DC
- Grant note
- R01 HL052901 || HL / National Heart, Lung, and Blood Institute : NHLBI
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000283810900015
- Scopus ID
- 2-s2.0-78650319041
- Other Identifier
- 991019169675304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Organic
- Polymer Science