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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Neural correlates of cognitive decline in ALS: An fNIRS study of the prefrontal cortex
Cognitive neuroscience, v 4(2), pp 115-121
01 Jun 2013
PMID: 24073736
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Functional near infrared spectroscopy (fNIRS) is a clinically feasible functional neuroimaging modality for detecting early cortical changes due to neurodegenerative diseases that affect cognition. The objective of this preliminary investigation was to test for reduced prefrontal activity in persons with cognitive impairments due to amyotrophic lateral sclerosis (ALS). Participants were required to complete two N-back working memory tasks of increasing complexity during fNIRS recordings. Five participants with ALS and age- and gender-matched healthy participants comprised the experimental and control groups, respectively. Significant reductions in prefrontal oxygenation levels were observed for the left and right hemispheres in the ALS group compared to the control group. Reduced prefrontal activation despite intact behavioral performance for a working memory task may suggest early neuroanatomical, neurophysiological and/or compensatory mechanisms in affected individuals. The fNIRS-derived oxygenation measure shows promise as a sensitive neural marker to identify early neuropsychological impairments due to ALS.
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Details
- Title
- Neural correlates of cognitive decline in ALS: An fNIRS study of the prefrontal cortex
- Creators
- Mili S Kuruvilla (Corresponding Author) - University of Nebraska Medical CenterJordan R Green - Massachusetts General Hospital , Institute of Health ProfessionsHasan Ayaz - Drexel University, School of Biomedical Engineering, Science & Health SystemsDaniel L Murman - Department of Neurological Sciences , University of Nebraska Medical Center
- Publication Details
- Cognitive neuroscience, v 4(2), pp 115-121
- Publisher
- Psychology Press
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000319495100008
- Scopus ID
- 2-s2.0-84878668190
- Other Identifier
- 991014878312004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences