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Journal article
Neural ensemble dynamics in trunk and hindlimb sensorimotor cortex encode for the control of postural stability
Cell reports (Cambridge), v 42(4), 112347
25 Apr 2023
PMID: 37027302
Abstract
The cortex has a disputed role in monitoring postural equilibrium and intervening in cases of major postural disturbances. Here, we investigate the patterns of neural activity in the cortex that underlie neural dynamics during unexpected perturbations. In both the primary sensory (S1) and motor (M1) cortices of the rat, unique neuronal classes differentially covary their responses to distinguish different characteristics of applied postural perturbations; however, there is substantial information gain in M1, demonstrating a role for higher-order computations in motor control. A dynamical systems model of M1 activity and forces generated by the limbs reveals that these neuronal classes contribute to a low-dimensional manifold comprised of sepa-rate subspaces enabled by congruent and incongruent neural firing patterns that define different computa-tions depending on the postural responses. These results inform how the cortex engages in postural control, directing work aiming to understand postural instability after neurological disease.
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Details
- Title
- Neural ensemble dynamics in trunk and hindlimb sensorimotor cortex encode for the control of postural stability
- Creators
- Gregory D. Disse - University of California, DavisBharadwaj Nandakumar - Drexel UniversityFrancois P. Pauzin - Univ Calif Davis, Biomed Engn, Davis, CA 95616 USAGary H. Blumenthal - Drexel Univ, Sch Biomed Engn Sci & Hlth Syst, Philadelphia, PA 19104 USAZhaodan Kong - University of California, DavisJochen Ditterich - University of California, DavisKaren A. Moxon - Drexel University, School of Biomedical Engineering, Science, and Health Systems
- Publication Details
- Cell reports (Cambridge), v 42(4), 112347
- Publisher
- Elsevier
- Number of pages
- 18
- Grant note
- 1993751 / NSF DARE grant UL1 TR001860; TL1 TR001861 / NIH NCATS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000975139800001
- Scopus ID
- 2-s2.0-85163218342
- Other Identifier
- 991021861169604721
InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology