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Neural mechanisms in cardiac arrhythmias associated with epileptogenic activity: The effect of phenobarbital in the cat
Journal article   Peer reviewed

Neural mechanisms in cardiac arrhythmias associated with epileptogenic activity: The effect of phenobarbital in the cat

Claire M. Lathers, Paul L. Schraeder and Shirley B. Carnel
Life sciences (1973), v 34(20), pp 1919-1936
1984
DOI: https://doi.org/10.1016/0024-3205(84)90123-1
PMID: 6727547
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Sudden unexplained death accounts for 5–17% of mortality in epileptic persons; autonomic dysfunction is thought to be a contributing factor. This paper describes the effect of phenobarbital (PB) pretreatment (20 mg/kg, i.v.) one hour prior to pentylenetetrazol (PTZ) 10, 20, 50, 100, 200, and 2000 mg/kg, i.v. given at ten minute intervals on autonomic parameters in the cat. PB depressed heart rate, blood pressure, and postganglionic cardiac sympathetic neural discharge, but did not significantly alter vagal discharge. PB shifted the peak duration of interictal activity from a lower to a higher dose of PTZ without affecting the average duration across doses. PB also significantly diminished the increases in heart rate and blood pressure induced by PTZ but altered neither the occurrence of arrhytmias nor the changes in cardiac autonomic neural discharge. Thus, PB appears to prevent only some forms of autonomic dysfunction associated with epileptogenic activity in this model.

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15 citations in Web of Science
20 citations in Scopus

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Web of Science research areas
Medicine, Research & Experimental
Pharmacology & Pharmacy
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