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Neural organization of spoken language revealed by lesion-symptom mapping
Journal article   Open access   Peer reviewed

Neural organization of spoken language revealed by lesion-symptom mapping

Daniel Mirman, Qi Chen, Yongsheng Zhang, Ze Wang, Olufunsho K Faseyitan, H Branch Coslett and Myrna F Schwartz
Nature communications, v 6(1), 6762
16 Apr 2015
PMID: 25879574
url
https://doi.org/10.1038/ncomms7762View
Published, Version of Record (VoR)CC BY V4.0 Open

Abstract

Adult Aged Anomia - etiology Anomia - physiopathology Aphasia - etiology Aphasia - physiopathology Aphasia, Broca - etiology Aphasia, Broca - physiopathology Aphasia, Conduction - etiology Aphasia, Conduction - physiopathology Brain - physiopathology Brain Mapping Female Frontal Lobe - physiopathology Humans Male Middle Aged Neural Pathways - physiopathology Recognition (Psychology) Speech - physiology Speech Perception - physiology Stroke - complications Stroke - physiopathology Temporal Lobe - physiopathology White Matter - physiopathology ESI Highly Cited Paper (Incites) Neuroimaging Semantics
Studies of patients with acquired cognitive deficits following brain damage and studies using contemporary neuroimaging techniques form two distinct streams of research on the neural basis of cognition. In this study, we combine high-quality structural neuroimaging analysis techniques and extensive behavioural assessment of patients with persistent acquired language deficits to study the neural basis of language. Our results reveal two major divisions within the language system-meaning versus form and recognition versus production-and their instantiation in the brain. Phonological form deficits are associated with lesions in peri-Sylvian regions, whereas semantic production and recognition deficits are associated with damage to the left anterior temporal lobe and white matter connectivity with frontal cortex, respectively. These findings provide a novel synthesis of traditional and contemporary views of the cognitive and neural architecture of language processing, emphasizing dual routes for speech processing and convergence of white matter tracts for semantic control and/or integration.

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Web of Science research areas
Neurosciences
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