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Journal article
Neural organization of spoken language revealed by lesion-symptom mapping
Nature communications, v 6(1), 6762
16 Apr 2015
PMID: 25879574
Abstract
Studies of patients with acquired cognitive deficits following brain damage and studies using contemporary neuroimaging techniques form two distinct streams of research on the neural basis of cognition. In this study, we combine high-quality structural neuroimaging analysis techniques and extensive behavioural assessment of patients with persistent acquired language deficits to study the neural basis of language. Our results reveal two major divisions within the language system-meaning versus form and recognition versus production-and their instantiation in the brain. Phonological form deficits are associated with lesions in peri-Sylvian regions, whereas semantic production and recognition deficits are associated with damage to the left anterior temporal lobe and white matter connectivity with frontal cortex, respectively. These findings provide a novel synthesis of traditional and contemporary views of the cognitive and neural architecture of language processing, emphasizing dual routes for speech processing and convergence of white matter tracts for semantic control and/or integration.
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Details
- Title
- Neural organization of spoken language revealed by lesion-symptom mapping
- Creators
- Daniel Mirman - Drexel UniversityQi Chen - Moss Rehabilitation HospitalYongsheng Zhang - University of PennsylvaniaZe Wang - University of PennsylvaniaOlufunsho K Faseyitan - University of PennsylvaniaH Branch Coslett - University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USAMyrna F Schwartz - University of Pennsylvania
- Publication Details
- Nature communications, v 6(1), 6762
- Publisher
- Springer Nature
- Grant note
- R01DC010805 / NIDCD NIH HHS R01DC000191 / NIDCD NIH HHS R01 DC000191 / NIDCD NIH HHS R01 DC010805 / NIDCD NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000353702500002
- Scopus ID
- 2-s2.0-84928007832
- Other Identifier
- 991021866807904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences