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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Neural progenitors proliferation is inhibited by EphB3 in the developing subventricular zone
International journal of developmental neuroscience, v 29(1), pp 9-14
01 Feb 2011
PMID: 20969945
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The subventricular zone (SVZ) of the mammalian forebrain is a major source of multipotent stem cells during development, and contributes to neurogenesis throughout the lifespan of the organism. Several studies described molecules regulating adult neurogenesis, however, few of them have examined neurogenesis in the early postnatal period. Adult neurogenesis is regulated in part by ephrinB3 and its receptors, so we examined the role of EphB3 on neural stem/progenitor cell (NSPC) proliferation in early postnatal development in the SVZ. To examine NSPC proliferation, we used BrdU incorporation in both cultured NSPCs and neonatal gene-targeted knockout mice, as well as Ki67 immunostaining in EphB3(-/-) mice. We observed a significant increase in proliferation in cultured NSPCs derived from EphB3(-/-) mice and in the SVZ of EphB3(-/-) mice. These studies support an anti-proliferative role for EphB3 in regulating NSPC numbers in the developing SVZ. (C) 2010 ISDN. Published by Elsevier Ltd. All rights reserved.
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Details
- Title
- Neural progenitors proliferation is inhibited by EphB3 in the developing subventricular zone
- Creators
- Kara del Valle - University of MiamiMichelle H. Theus - University of MiamiJohn R. Bethea - University of MiamiDaniel J. Liebl - University of MiamiJerome Ricard - University of Miami
- Publication Details
- International journal of developmental neuroscience, v 29(1), pp 9-14
- Publisher
- Elsevier
- Number of pages
- 6
- Grant note
- NS049545; NS30291 / NIH/NINDS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) Miami Project R01NS051709 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; College of Arts and Sciences; Drexel University
- Web of Science ID
- WOS:000286846500002
- Scopus ID
- 2-s2.0-78650173365
- Other Identifier
- 991020099699204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Developmental Biology
- Neurosciences