Journal article
Neuritic Pathology as a Correlate of Synaptic Loss in Dementia With Lewy Bodies
American journal of Alzheimer's disease and other dementias, v 23(1), pp 97-102
Feb 2008
PMID: 18276962
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Synaptic loss is present in Alzheimer's disease and correlates with the severity of dementia. Loss of synapses in dementia with Lewy bodies (DLB) does not correlate as clearly with cognitive status and its cause is unclear. To begin to understand the relationship between cognition and synaptic loss in DLB, we assessed immunoreactivity for the synaptic-terminal specific protein, synaptophysin, in the hippocampus in 14 DLB cases. Quantitative synaptic data were obtained using an Image-Pro semiautomated analysis system. We determined Braak stage, β-amyloid, Lewy bodies (LBs), and Lewy neurites (LN). We found significant correlations (r = 0.617, P < .01) between Braak stage and synaptophysin score and marginal correlation between LN score and synaptophysin loss ( r = 0.694, P < .06). Correlations of β-amyloid and of LB density with synaptophysin score were unimpressive. These data support the hypothesis that synaptic loss in DLB is related to neuritic degeneration.
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Details
- Title
- Neuritic Pathology as a Correlate of Synaptic Loss in Dementia With Lewy Bodies
- Creators
- Gonzalo J. Revuelta - Drexel UniversityAndrea Rosso - Drexel UniversityCarol F. Lippa - Drexel University
- Publication Details
- American journal of Alzheimer's disease and other dementias, v 23(1), pp 97-102
- Publisher
- SAGE Publications
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000258887600011
- Scopus ID
- 2-s2.0-42949093121
- Other Identifier
- 991019312435904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Geriatrics & Gerontology