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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Neuro-immune dysfunction during brain aging: new insights in microglial cell regulation
Current opinion in pharmacology, v 26, pp 96-101
01 Feb 2016
PMID: 26595306
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Microglia, the resident immune cells of the brain, are at the center of communication between the central nervous system and immune system. While these brain-immune interactions are balanced in healthy adulthood, the ability to maintain homeostasis during aging is impaired. Microglia develop a loss of integrated regulatory networks including aberrant signaling from other brain cells, immune sensors, and epigenetic modifiers. The low-grade chronic neuroinflammation associated with this dysfunctional activity likely contributes to cognitive deficits and susceptibility to age-related pathologies. A better understanding of the underlying mechanisms responsible for neuro-immune dysregulation with age is crucial for providing targeted therapeutic strategies to support brain repair and healthy aging.
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Details
- Title
- Neuro-immune dysfunction during brain aging: new insights in microglial cell regulation
- Creators
- Stephanie M. Matt - University of Illinois Urbana-ChampaignRodney W. Johnson - University of Illinois Urbana-Champaign
- Publication Details
- Current opinion in pharmacology, v 26, pp 96-101
- Publisher
- Elsevier
- Number of pages
- 6
- Grant note
- R01HD069899 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) R01 AG16710; HD069899 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01AG016710 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000369208300015
- Scopus ID
- 2-s2.0-84947080762
- Other Identifier
- 991021902508304721
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- Web of Science research areas
- Pharmacology & Pharmacy