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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Neuroactive diol and acyloin metabolites from cone snail-associated bacteria
Bioorganic & medicinal chemistry letters, v 23(17), pp 4867-4869
01 Sep 2013
PMID: 23880542
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The bacterium Gordonia sp. 647W.R.1a.05 was cultivated from the venom duct of the cone snail, Conus circumcisus. The Gordonia sp. organic extract modulated the action potential of mouse dorsal root ganglion neurons. Assay-guided fractionation led to the identification of the new compound circumcin A (1) and 11 known analogs (2–12). Two of these compounds, kurasoin B (7) and soraphinol A (8), were active in a human norepinephrine transporter assay with Ki values of 2575 and 867nM, respectively. No neuroactivity had previously been reported for compounds in this structural class. Gordonia species have been reproducibly isolated from four different cone snail species, indicating a consistent association between these organisms.
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Details
- Title
- Neuroactive diol and acyloin metabolites from cone snail-associated bacteria
- Creators
- Zhenjian Lin - University of MontanaLenny Marett - University of UtahRonald W. Hughen - University of UtahMalem Flores - University of the Philippines SystemImelda Forteza - University of the Philippines SystemMary Anne Ammon - University of the Philippines SystemGisela P. Concepcion - University of the Philippines SystemSamuel Espino - University of UtahBaldomero M. Olivera - University of UtahGary Rosenberg - Drexel UniversityMargo G. Haygood - Oregon Health & Science UniversityAlan R. Light - University of UtahEric W. Schmidt - University of Montana
- Publication Details
- Bioorganic & medicinal chemistry letters, v 23(17), pp 4867-4869
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biodiversity, Earth, and Environmental Science (BEES); Malacology
- Web of Science ID
- WOS:000323187000024
- Scopus ID
- 2-s2.0-84881373386
- Other Identifier
- 991019168143704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Medicinal
- Chemistry, Organic