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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Neurocognitive Effects of HIV, Hepatitis C, and Substance Use History
Journal of the International Neuropsychological Society, v 18(1), pp 68-78
01 Jan 2012
PMID: 22132928
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
HIV-associated neurocognitive dysfunction persists in the highly active antiretroviral therapy (HAART) era and may be exacerbated by comorbidities, including substance use and hepatitis C virus (HCV) infection. However, the neurocognitive impact of HIV, HCV, and substance use in the HAART era is still not well understood. In the current study, 115 HIV-infected and 72 HIV-seronegative individuals with significant rates of lifetime substance dependence and HCV infection received comprehensive neuropsychological assessment. We examined the effects of HIV serostatus, HCV infection, and substance use history on neurocognitive functioning. We also examined relationships between HIV disease measures (current and nadir CD4, HIV RNA, duration of infection) and cognitive functioning. Approximately half of HIV-infected participants exhibited neurocognitive impairment. Detectable HIV RNA but not HIV serostatus was significantly associated with cognitive functioning. HCV was among the factors most consistently associated with poorer neurocognitive performance across domains, while substance use was less strongly associated with cognitive performance. The results suggest that neurocognitive impairment continues to occur in HIV-infected individuals in association with poor virologic control and comorbid conditions, particularly HCV coinfection. (JINS, 2012, 18, 68-78)
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Details
- Title
- Neurocognitive Effects of HIV, Hepatitis C, and Substance Use History
- Creators
- Kathryn N. Devlin - Miriam HospitalAssawin Gongvatana - Miriam HospitalUraina S. Clark - Miriam HospitalJesse D. Chasman - Brown UniversityMichelle L. Westbrook - Miriam HospitalKaren T. Tashima - Miriam HospitalBradford Navia - Tufts UniversityRonald A. Cohen - Brown University
- Publication Details
- Journal of the International Neuropsychological Society, v 18(1), pp 68-78
- Publisher
- Cambridge Univ Press
- Number of pages
- 11
- Grant note
- R01 MH074368 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA K99AA020235 / NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) R01MH074368 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) P30 AI042853 / Lifespan/Tufts/Brown Center for AIDS Research P30AI042853 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000298958800007
- Scopus ID
- 2-s2.0-84855184670
- Other Identifier
- 991021463689704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences
- Psychiatry
- Psychology