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Published, Version of Record (VoR)Open Access (License Unspecified), Open
Journal article
Neurocognitive contributions to verbal fluency deficits in frontotemporal lobar degeneration
Neurology, v 73(7), pp 535-542
18 Aug 2009
PMID: 19687454
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: To test the hypothesis that different neurocognitive networks underlie verbal fluency deficits in frontotemporal lobar degeneration (FTLD).
Methods: Letter ("FAS") and semantic ("animal") fluency tests were administered to patients with a behavioral/dysexecutive disorder (bvFTLD; n = 71), semantic dementia (SemD; n = 21), and progressive nonfluent aphasia (PNFA; n = 26). Tests measuring working memory, naming/lexical retrieval, and semantic knowledge were also obtained. MRI voxel-based morphometry (VBM) studies were obtained on a subset of these patients (bvFTLD, n = 51; PNFA, n = 11; SemD, n = 10).
Results: Patients with SemD were disproportionately impaired on the semantic fluency measure. Reduced output on this test was correlated with impaired performance on naming/lexical retrieval tests. VBM analyses related reduced letter and semantic fluency to anterior and inferior left temporal lobe atrophy. Patients with bvFTLD were equally impaired on both fluency tests. Poor performance on both fluency tests was correlated with low scores on working memory and naming/lexical retrieval measures. In this group, MRI-VBM analyses related letter fluency to bilateral frontal atrophy and semantic fluency to left frontal/temporal atrophy. Patients with PNFA were also equally impaired on fluency tests. Reduced semantic fluency output was correlated with reduced performance on naming/lexical retrieval tests. MRI-VBM analyses related semantic fluency to the right frontal lobe and letter fluency to left temporal atrophy.
Conclusions: Distinct neurocognitive networks underlie impaired performance on letter and semantic fluency tests in frontotemporal lobar degeneration subgroups. Neurology (R) 2009;73:535-542
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Details
- Title
- Neurocognitive contributions to verbal fluency deficits in frontotemporal lobar degeneration
- Creators
- D. J. Libon - Drexel UniversityC. McMillan - Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USAD. Gunawardena - Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USAC. Powers - Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USAL. Massimo - Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USAA. Khan - Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USAB. Morgan - Supreme Council Of HealthC. Farag - Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USAL. Richmond - Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USAJ. Weinstein - Supreme Council Of HealthP. Moore - Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USAH. B. Coslett - Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USAA. Chatterjee - Supreme Council Of HealthG. Aguirre - Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USAM. Grossman - Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA
- Publication Details
- Neurology, v 73(7), pp 535-542
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 8
- Grant note
- R01 AG015116; AG15116; AG10124; P01 AG017586; AG17586 / NIA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) R01NS035867 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) MH076227; R01 MH076227 / NIMH NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01 NS044266; R01 NS048130; R01 NS035867; NS08130; NS44266 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01MH076227 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01AG015116 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Health Management and Policy
- Web of Science ID
- WOS:000269038300008
- Scopus ID
- 2-s2.0-69449103433
- Other Identifier
- 991019168246704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology