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Journal article
Neuroergonomic assessment of developmental coordination disorder
Scientific reports, v 12(1), 10239
01 Jan 2022
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Until recently, neural assessments of gross motor coordination could not reliably handle active tasks, particularly in realistic environments, and offered a narrow understanding of motor-cognition. By applying a comprehensive neuroergonomic approach using optical mobile neuroimaging, we probed the neural correlates of motor functioning in young people with Developmental Coordination Disorder (DCD), a motor-learning deficit affecting 5–6% of children with lifelong complications. Neural recordings using fNIRS were collected during active ambulatory behavioral task execution from 37 Typically Developed and 48 DCD Children who performed cognitive and physical tasks in both single and dual conditions. This is the first of its kind study targeting regions of prefrontal cortical dysfunction for identification of neuropathophysiology for DCD during realistic motor tasks and is one of the largest neuroimaging study (across all modalities) involving DCD. We demonstrated that DCD is a motor-cognitive disability, as gross motor /complex tasks revealed neuro-hemodynamic deficits and dysfunction within the right middle and superior frontal gyri of the prefrontal cortex through functional near infrared spectroscopy. Furthermore, by incorporating behavioral performance, decreased neural efficiency in these regions were revealed in children with DCD, specifically during motor tasks. Lastly, we provide a framework, evaluating disorder impact in ecologically valid contexts to identify when and for whom interventional approaches are most needed and open the door for precision therapies.
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Details
- Title
- Neuroergonomic assessment of developmental coordination disorder
- Creators
- Shawn Joshi (Corresponding Author) - Drexel UniversityBenjamin D Weedon - Oxford Brookes UniversityPatrick Esser - Oxford Brookes UniversityYan-Ci Liu - Oxford Brookes UniversityDaniella N Springett - Oxford Brookes UniversityAndy Meaney - Oxford Brookes UniversityMario Inacio - Oxford Brookes UniversityAnne Delextrat - Oxford Brookes UniversitySteve Kemp - Oxford Brookes UniversityTomás Ward - Dublin City UniversityHooshang Izadi - Oxford Brookes UniversityHelen Dawes - University of OxfordHasan Ayaz - Drexel University
- Publication Details
- Scientific reports, v 12(1), 10239
- Publisher
- Nature Publishing Group
- Number of pages
- 14
- Grant note
- Research reported in this paper was supported by the Action Medical Research and the Chartered Society of Physiotherapy Charitable Trust (ref GN2445), and by the CLEAR trust. Shawn Joshi was supported by the Fulbright US-UK Fellowship, and the research reported in this publication was supported by the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health under Award Number F30HD103527. Tomás Ward is funded by Allied Irish Banks and Science Foundation Ireland (Grant No. SFI/12/RC/2289_P2). Helen Dawes is supported by the Elizabeth Casson Trust and the NIHR Oxford Health Biomedical Research Centre. Hasan Ayaz was supported by the Eunice Kennedy Shriver National Institute of Child Health & Development, National Institute of Drug Abuse, and the National Institute of Nursing Research of the National Institutes of Health and the Pennsylvania Department of Health, National Science Foundation, and Air Force Ofce of Scientifc Research. Te content/views expressed are and is solely the responsibility of the authors and does not necessarily represent the ofcial views of the National Institutes of Health, NHS, the NIHR or the Department of Health.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000812565400104
- Scopus ID
- 2-s2.0-85132113145
- Other Identifier
- 991019168629304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences