Journal article
Neuroimmune Mechanisms as Novel Treatment Targets for Substance Use Disorders and Associated Comorbidities
Frontiers in neuroscience, v 15, 650785
15 Apr 2021
PMID: 33935636
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recent studies examining the neurobiology of substance abuse have revealed a significant role of neuroimmune signaling as a mechanism through which drugs of abuse induce aberrant changes in synaptic plasticity and contribute to substance abuse-related behaviors. Immune signaling within the brain and the periphery critically regulates homeostasis of the nervous system. Perturbations in immune signaling can induce neuroinflammation or immunosuppression, which dysregulate nervous system function including neural processes associated with substance use disorders (SUDs). In this review, we discuss the literature that demonstrates a role of neuroimmune signaling in regulating learning, memory, and synaptic plasticity, emphasizing specific cytokine signaling within the central nervous system. We then highlight recent preclinical studies, within the last 5 years when possible, that have identified immune mechanisms within the brain and the periphery associated with addiction-related behaviors. Findings thus far underscore the need for future investigations into the clinical potential of immunopharmacology as a novel approach toward treating SUDs. Considering the high prevalence rate of comorbidities among those with SUDs, we also discuss neuroimmune mechanisms of common comorbidities associated with SUDs and highlight potentially novel treatment targets for these comorbid conditions. We argue that immunopharmacology represents a novel frontier in the development of new pharmacotherapies that promote long-term abstinence from drug use and minimize the detrimental impact of SUD comorbidities on patient health and treatment outcomes.
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Details
- Title
- Neuroimmune Mechanisms as Novel Treatment Targets for Substance Use Disorders and Associated Comorbidities
- Creators
- Mark D. Namba - Arizona State UniversityJonna M. Leyrer-Jackson - Arizona State UniversityErin K. Nagy - Arizona State UniversityM. Foster Olive - Arizona State UniversityJanet L. Neisewander - Arizona State University
- Publication Details
- Frontiers in neuroscience, v 15, 650785
- Publisher
- Frontiers Media Sa
- Number of pages
- 27
- Grant note
- Arizona State University Institute for Social Science Research seed grant F31 DA047072; R21 DA048651; R01 DA043172; R01 AA025590; F32 AA027962 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA G2019100191831450 / Sigma Xi ARCS Foundation Scholar Award
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000645105800001
- Scopus ID
- 2-s2.0-85104941423
- Other Identifier
- 991021955154204721
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- Web of Science research areas
- Neurosciences