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Journal article
Neuroimmune System as a Driving Force for Plasticity Following CNS Injury
Frontiers in cellular neuroscience, v 14, pp 187-187
23 Jul 2020
PMID: 32792908
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Following an injury to the central nervous system (CNS), spontaneous plasticity is observed throughout the neuraxis and affects multiple key circuits. Much of this spontaneous plasticity can elicit beneficialanddeleterious functional outcomes, depending on the context of plasticity and circuit affected. Injury-induced activation of the neuroimmune system has been proposed to be a major factor in driving this plasticity, as neuroimmune and inflammatory factors have been shown to influence cellular, synaptic, structural, and anatomical plasticity. Here, we will review the mechanisms through which the neuroimmune system mediates plasticity after CNS injury. Understanding the role of specific neuroimmune factors in driving adaptive and maladaptive plasticity may offer valuable therapeutic insight into how to promote adaptive plasticity and/or diminish maladaptive plasticity, respectively.
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Details
- Title
- Neuroimmune System as a Driving Force for Plasticity Following CNS Injury
- Creators
- Micaela L. O'Reilly - Drexel Univ, Coll Med, Marion Murray Spinal Cord Res Ctr, Dept Neurobiol & Anat, Philadelphia, PA 19104 USAVeronica J. Tom - Drexel University
- Publication Details
- Frontiers in cellular neuroscience, v 14, pp 187-187
- Publisher
- Frontiers Media Sa
- Number of pages
- 22
- Grant note
- R01 NS085426 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01 NS111761; R01 NS106908 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000560080900001
- Scopus ID
- 2-s2.0-85089221415
- Other Identifier
- 991019167467304721
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- Web of Science research areas
- Neurosciences