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Journal article
Neurointegrity and europhysiology: astrocyte, glutamate, and carbon monoxide interactions
Medical gas research, v 9(1), pp 24-45
01 Jan 2019
PMID: 30950417
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Astrocyte contributions to brain function and prevention of neuropathologies are as extensive as that of neurons. Astroglial regulation of glutamate, a primary neurotransmitter, is through uptake, release through vesicular and non-vesicular pathways, and catabolism to intermediates. Homeostasis by astrocytes is considered to be of primary importance in determining normal central nervous system health and central nervous system physiology - glutamate is central to dynamic physiologic changes and central nervous system stability. Gasotransmitters may affect diverse glutamate interactions positively or negatively. The effect of carbon monoxide, an intrinsic central nervous system gaso-transmitter, in the complex astrocyte homeostasis of glutamate may offer insights to normal brain development, protection, and its use as a neuromodulator and neurotherapeutic. In this article, we will review the effects of carbon monoxide on astrocyte homeostasis of glutamate.
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Details
- Title
- Neurointegrity and europhysiology: astrocyte, glutamate, and carbon monoxide interactions
- Creators
- Vicki L. Mahan - St. Christopher's Hospital for Children
- Publication Details
- Medical gas research, v 9(1), pp 24-45
- Publisher
- Wolters Kluwer Medknow Publications
- Number of pages
- 22
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000462964700004
- Scopus ID
- 2-s2.0-85063802341
- Other Identifier
- 991019167575104721
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- Web of Science research areas
- Medicine, Research & Experimental