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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Neurokinin-1 receptor signaling induces a pro-inflammatory transcriptomic profile in CD16+ monocytes
Journal of neuroimmunology, v 353, pp 577524-577524
15 Apr 2021
PMID: 33640716
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Neurokinin-1 receptor (NK1R) signaling can be immunomodulatory and it can lead to preferential transmigration of CD14+CD16+ monocytes across the blood brain barrier, potentially promoting the development of inflammatory neurological diseases, such as neuroHIV. To evaluate how NK1R signaling alters monocyte biology, RNA sequencing was used to define NK1R-mediated transcriptional changes in different monocyte subsets. The data show that NK1R activation induces a greater number of changes in CD14+CD16+ monocytes (152 differentially expressed genes), than in CD14+CD16- monocytes (36 genes), including increases in the expression of NF-κB and components of the NLRP3 inflammasome pathway. These results suggest that NK1R may alter the inflammatory state of CD14+CD16+ monocytes, influencing the development of neuroinflammation.
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Details
- Title
- Neurokinin-1 receptor signaling induces a pro-inflammatory transcriptomic profile in CD16+ monocytes
- Creators
- Vasiliki Pappa - Children's Hospital of PhiladelphiaSergei Spitsin - Children's Hospital of PhiladelphiaPeter J Gaskill - Drexel UniversitySteven D Douglas - University of Pennsylvania
- Publication Details
- Journal of neuroimmunology, v 353, pp 577524-577524
- Publisher
- Elsevier
- Grant note
- P30 MH097488 / NIMH NIH HHS R01 DA039005 / NIDA NIH HHS R21 DA049227 / NIDA NIH HHS U01 MH090325 / NIMH NIH HHS P01 MH105303 / NIMH NIH HHS R01 AI106509 / NIAID NIH HHS T32 AI007632 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000640524800001
- Scopus ID
- 2-s2.0-85101541913
- Other Identifier
- 991019167764004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Neurosciences