Journal article
Neuroleukemiosis: Diagnosis and management
Clinical neurology and neurosurgery, v 184, 105340
Sep 2019
PMID: 31387077
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
•Neuroleukemiosis involves peripheral nerve infiltration by leukemic cells.•Presentations include peripheral neuropathy and/or chloromatous masses.•Diagnosis is supported by electrophysiologic testing and imaging.•Diagnosis is established by biopsy and immunophenotyping.•Treatment options include surgical resection, chemotherapy, donor lymphocyte infusions, and irradiation.
An exceedingly rare manifestation of leukemia, termed neuroleukemiosis, involves peripheral nerve infiltration by leukemic cells. Patients with neuroleukemiosis typically present with a peripheral neuropathy and/or chloromatous masses. The diagnosis is supported by, and established with, electrophysiologic testing, imaging, histopathology, and immunophenotyping. We present the case of 21 year old male with multiply relapsed M4 type of acute myelogenous leukemia (AML) who presented with extremity pain and was subsequently found to have multiple cervical, thoracic, and lumbosacral nerve root masses. A diagnosis of neuroleukemiosis was established via CT-guided biopsy and immunophenotyping. The patient’s neuroleukemiosis responded well to chemotherapy, donor lymphocyte infusions, and spinal irradiation. The literature is reviewed regarding this interesting and rare clinical condition.
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Details
- Title
- Neuroleukemiosis: Diagnosis and management
- Creators
- Christine Mau - Penn State Milton S. Hershey Medical CenterMichael G.Z. Ghali - Penn State Milton S. Hershey Medical CenterMichael Styler - Hahnemann University HospitalJozef Malysz - Penn State Milton S. Hershey Medical CenterCharles S. Specht - Penn State Milton S. Hershey Medical CenterElias Rizk - Penn State Milton S. Hershey Medical Center
- Publication Details
- Clinical neurology and neurosurgery, v 184, 105340
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000482873200006
- Scopus ID
- 2-s2.0-85070004440
- Other Identifier
- 991019312383704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Surgery