Journal article
Neurological Complications of Rheumatic Disease
Seminars in pediatric neurology, v 24(1), pp 54-59
Feb 2017
PMID: 28779866
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Rheumatic disease represents a broad spectrum of systemic conditions manifested by multisystem involvement and mediated by autoimmunity and inflammation. Their neurological complications may occur at any point in the disease process and are diagnostically challenging. For years central nervous system (CNS) was considered as a system uniquely protected from effects of the immune system because of the blood-brain barrier. Indeed, under physiological conditions immune access to CNS is tightly regulated. Over the past decade, new scientific discoveries highlighted pathways by which immune and neurological systems interact, including a variety of mechanisms controlling permeability of blood-brain barrier, and specific roles that CD4
and CD8
T-lymphocytes play in initiation of specific adaptive immune response to neural specific antigens. This leads to release of proinflammatory cytokines (interleukin 1, interleukin 6, and tumor necrosis factor alpha). In addition, B-cells involved in CNS inflammation produce antibodies against membrane bound and soluble antigens. This article describes specific neurological manifestations of the most common autoimmune rheumatic disorders.
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Details
- Title
- Neurological Complications of Rheumatic Disease
- Creators
- Svetlana Lvovich - St. Christopher's Hospital for ChildrenDonald P Goldsmith - St. Christopher's Hospital for Children
- Publication Details
- Seminars in pediatric neurology, v 24(1), pp 54-59
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000407527900007
- Scopus ID
- 2-s2.0-85020127242
- Other Identifier
- 991019167641404721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Pediatrics