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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Neurological Gait Abnormalities Moderate the Functional Brain Signature of the Posture First Hypothesis
Brain topography, v 29(2), pp 334-343
Mar 2016
PMCID: PMC4755880
PMID: 26613725
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The posture first hypothesis suggests that under dual-task walking conditions older adults prioritize gait over cognitive task performance. Functional neural confirmation of this hypothesis, however, is lacking. Herein, we determined the functional neural correlates of the posture first hypothesis and hypothesized that the presence of neurological gait abnormalities (NGA) would moderate associations between brain activations, gait and cognitive performance. Using functional near-infrared spectroscopy we assessed changes in oxygenated hemoglobin levels in the pre-frontal cortex (PFC) during normal walk and walk while talk (WWT) conditions in a large cohort of non-demented older adults (n = 236; age = 75.5 ± 6.49 years; female = 51.7 %). NGA were defined as central (due to brain diseases) or peripheral (neuropathic gait) following a standardized neurological examination protocol. Double dissociations between brain activations and behavior emerged as a function of NGA. Higher oxygenation levels during WWT were related to better cognitive performance (estimate = 0.145; p < 0.001) but slower gait velocity (estimate = -6.336, p < 0.05) among normals. In contrast, higher oxygenation levels during WWT among individuals with peripheral NGA were associated with worse cognitive performance (estimate = -0.355; p < 0.001) but faster gait velocity (estimate = 14.855; p < 0.05). Increased activation in the PFC during locomotion may have a compensatory function that is designed to support gait among individuals with peripheral NGA.
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Details
- Title
- Neurological Gait Abnormalities Moderate the Functional Brain Signature of the Posture First Hypothesis
- Creators
- Roee Holtzer - Albert Einstein College of MedicineJoe Verghese - Albert Einstein College of MedicineGilles Allali - Albert Einstein College of MedicineMeltem Izzetoglu - Drexel UniversityCuiling Wang - Albert Einstein College of MedicineJeannette R Mahoney - Albert Einstein College of Medicine
- Publication Details
- Brain topography, v 29(2), pp 334-343
- Publisher
- Springer Nature
- Grant note
- R01AG044007 / NIA NIH HHS R01 AG036921 / NIA NIH HHS R01AG036921 / NIA NIH HHS R01 AG044007 / NIA NIH HHS UL1 TR001073 / NCATS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Marketing
- Web of Science ID
- WOS:000370357300012
- Scopus ID
- 2-s2.0-84958175825
- Other Identifier
- 991019173426104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences