Journal article
Neuromyelitis optica IgG status in acute partial transverse myelitis
Archives of neurology (Chicago), v 63(10), pp 1398-1400
Oct 2006
PMID: 17030654
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Neuromyelitis optica (NMO) IgG is a specific marker for NMO. Furthermore, a high proportion of patients with longitudinally extensive transverse myelitis (characterized by spinal cord lesions extending 3 vertebral segments or more on magnetic resonance imaging) are seropositive for NMO-IgG and are considered to have a limited form of NMO. The NMO-IgG status in mild cases of acute partial transverse myelitis asociated with minimal magnetic resonance imaging abnormalities (spinal cord lesions <2 vertebral segments on magnetic resonance imaging) is unknown.
To investigate the NMO-IgG status of patients with acute partial transverse myelitis and a normal cerebral magnetic resonance image.
Observational, retrospective consecutive case series with longitudinal follow-up.
Allegheny Multiple Sclerosis Treatment Center.
Three groups of patients were tested for NMO-IgG. Group 1 consisted of 22 patients with acute partial transverse myelitis, group 2 consisted of 4 patients with definite NMO (by 1999 criteria of Wingerchuk et al), and group 3 consisted of 6 patients with definite multiple sclerosis.
NMO-IgG status. A commercially available assay for NMO antibodies was performed at the Mayo Clinic. Testing was performed during the convalescent stage of the illness.
Of the 22 patients with acute partial transverse myelitis, only 1 was seropositive for NMO-IgG at presentation. This patient subsequently developed recurrent episodes of longitudinally extensive transverse myelitis that are typicaly seen in association with NMO-IgG. Three of the 4 patients meeting criteria for NMO were seropositive. None of the patients with multiple sclerosis had NMO-IgG detected.
NMO-IgG is rarely encountered in patients with acute partial transverse myelitis, which is in sharp contrast to the high frequency of this antibody in patients with NMO and longitudinally extensive transverse myelitis.
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Details
- Title
- Neuromyelitis optica IgG status in acute partial transverse myelitis
- Creators
- Thomas F Scott - Drexel UniversitySalima L Kassab - Allegheny General HospitalSean J Pittock
- Publication Details
- Archives of neurology (Chicago), v 63(10), pp 1398-1400
- Publisher
- American Medical Association
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000241057400007
- Scopus ID
- 2-s2.0-33749604596
- Other Identifier
- 991019167415804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology