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Journal article
Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease
Neurobiology of disease, v 17(1), pp 108-113
2004
PMID: 15350971
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
An in situ approach was used to identify the oxidized RNA nucleoside 8-hydroxyguanosine (8OHG) in the frontal cortex of familial Alzheimer's disease (FAD) with a mutation in presenilin-1 (PS-1) or amyloid β protein precursor (AβPP) gene (
n = 13, age 47–81 years). Neurons with marked 8OHG immunoreaction in the cytoplasm were widely distributed in the superior/middle frontal gyrus of FAD. Relative intensity measurements of neuronal 8OHG immunoreactivity showed that there was a significant increase in FAD compared with controls (
n = 15, age 59–81 years), while there was no difference in relative 8OHG between the PS-1 and the AβPP FAD. Interestingly, a presymptomatic case carrying a PS-1 mutation showed a considerable level of relative 8OHG, and the increased levels of neuronal 8OHG in FAD were more prominent in cases with a lower percentage area of Aβ42 burden. These results suggest that oxidative stress is an early event involved in the pathological cascade of FAD.
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Details
- Title
- Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease
- Creators
- Akihiko Nunomura - Asahikawa Medical College HospitalShigeru Chiba - Asahikawa Medical UniversityCarol F. Lippa - Drexel UniversityPatrick Cras - University of AntwerpRajesh N. Kalaria - Wolfson Unit, Institute for Ageing and Health, Newcastle General Hospital, Newcastle-upon-Tyne NE4 6BE, UKAtsushi Takeda - Tohoku UniversityKazuhiro Honda - Case Western Reserve UniversityMark A. Smith - Case Western Reserve UniversityGeorge Perry - Case Western Reserve University
- Publication Details
- Neurobiology of disease, v 17(1), pp 108-113
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000223944200012
- Scopus ID
- 2-s2.0-4444302948
- Other Identifier
- 991019312357404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences