Journal article
Neuronal microtubules: when the MAP is the roadblock
Trends in cell biology, v 15(4)
Apr 2005
PMID: 15817373
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recent studies shed new light on a potential cascade of events by which neurological diseases such as Alzheimer's lead to axonal degeneration. In this model, the pathology starts with an elevation in microtubule-associated proteins (MAPs) such as tau. This renders the microtubules less accessible to motor proteins, which impairs their capacity to sustain anterograde axonal transport of proteins and organelles. In response, the neuron hyperphosphorylates tau so that it dissociates from the microtubules. Unfortunately, the hyperphosphorylated tau forms abnormal filaments that are deleterious to the axon, and the tau-depleted microtubules become highly sensitive to microtubule-severing proteins such as katanin.
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Details
- Title
- Neuronal microtubules: when the MAP is the roadblock
- Creators
- Peter W Baas - Drexel University College of Medicine, Dept of Neurobiology and Anatomy, 2900 W. Queen Lane, Philadelphia, PA 19129, USA. Peter.W.Baas@drexel.eduLiang Qiang
- Publication Details
- Trends in cell biology, v 15(4)
- Publisher
- Elsevier; England
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000228847900002
- Scopus ID
- 2-s2.0-16844379161
- Other Identifier
- 991014877888304721
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- Web of Science research areas
- Cell Biology