Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Neuronal progenitor transplantation and respiratory outcomes following upper cervical spinal cord injury in adult rats
Experimental neurology, v 225(1), pp 231-236
01 Sep 2010
PMID: 20599981
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Despite extensive gray matter loss following spinal cord injury (SCI), little attention has been given to neuronal replacement strategies and their effects on specific functional circuits in the injured spinal cord. In the present study, we assessed breathing behavior and phrenic nerve electrophysiological activity following transplantation of microdissected dorsal or ventral pieces of rat fetal spinal cord tissue (FSCD or FSCV, respectively) into acute, cervical (C2) spinal hemisections. Transneuronal tracing demonstrated connectivity between donor neurons from both sources and the host phrenic circuitry. Phrenic nerve recordings revealed differential effects of dorsally vs. ventrally derived neural progenitors on ipsilateral phrenic nerve recovery and activity. These initial results suggest that local gray matter repair can influence motoneuron function in targeted circuits following spinal cord injury and that outcomes will be dependent on the properties and phenotypic fates of the donor cells employed. (C) 2010 Elsevier Inc. All rights reserved.
Metrics
Details
- Title
- Neuronal progenitor transplantation and respiratory outcomes following upper cervical spinal cord injury in adult rats
- Creators
- Todd E. White - McKnight Brain InstituteMichael A. Lane - McKnight Brain InstituteMilapjit S. Sandhu - University of Florida College of Public Health and Health ProfessionsBarbara E. O'Steen - McKnight Brain InstituteDavid D. Fuller - University of Florida College of Public Health and Health ProfessionsPaul J. Reier - McKnight Brain Institute
- Publication Details
- Experimental neurology, v 225(1), pp 231-236
- Publisher
- Elsevier
- Number of pages
- 6
- Grant note
- RO1NS054025 / NIH NINDS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) Anne and Oscar Lackner Chair in Medicine R01NS054025 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) P40RR018604 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000281339300029
- Scopus ID
- 2-s2.0-77955665246
- Other Identifier
- 991019299115104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences