Journal article
Neurons in rat orbitofrontal cortex and medial prefrontal cortex exhibit distinct responses in reward and strategy-update in a risk-based decision-making task
Metabolic brain disease, v 34(2), pp 417-429
01 Apr 2019
PMID: 30535618
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The orbitofrontal cortex (OFC) and the medial prefrontal cortex (mPFC) are known to participate in risk-based decision-making. However, whether neuronal activities of these two brain regions play similar or differential roles during different stages of risk-based decision-making process remains unknown. Here we conducted multi-channel in vivo recordings in the OFC and mPFC simultaneously when rats were performing a gambling task. Rats were trained to update strategy as the task was shifted in two stages. Behavioral testing suggests that rats exhibited different risk preferences and response latencies to food rewards during stage-1 and stage-2. Indeed, the firing patterns and numbers of non-specific neurons and nosepoking-predicting neurons were similar in OFC and mPFC. However, there were no reward-expecting neurons and significantly more reward-excitatory neurons (fired as rats received rewards) in the mPFC. Further analyses suggested that nosepoking-predicting neurons may encode the overall value of reward and strategy, whereas reward-expecting neurons show more intensive firing to a big food reward in the OFC. Nosepoking-predicting neurons in mPFC showed no correlation with decision-making strategy updating, whereas the response of reward-excitatory neurons in mPFC, which were barely observed in OFC, were inhibited during nosepoking, but were enhanced in the post-nosepoking period. These findings indicate that neurons in the OFC and mPFC exhibit distinct responses in decision-making process during reward consumption and strategy updating. Specifically, OFC encodes the overall value of a choice and is thus important for learning and strategy updating, whereas mPFC plays a key role in monitoring and execution of a strategy.
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Details
- Title
- Neurons in rat orbitofrontal cortex and medial prefrontal cortex exhibit distinct responses in reward and strategy-update in a risk-based decision-making task
- Creators
- Dan-Dan Hong - Capital Normal UniversityWen-Qiang Huang - Capital Normal UniversityAi-Ai Ji - Capital Normal UniversitySha-Sha Yang - Capital Normal UniversityHui Xu - University of UtahKe-Yi Sun - Capital Normal UniversityAihua Cao - Qilu Hospital of Shandong UniversityWen-Jun Gao - Drexel UniversityNing Zhou - The General Hospital of Chinese People's Liberation Army, Beijing, 100853, China.Ping Yu - Capital Normal University
- Publication Details
- Metabolic brain disease, v 34(2), pp 417-429
- Publisher
- Springer Nature
- Number of pages
- 13
- Grant note
- KM201410028019 / Science and Technology Project of Beijing Municipal Education Commission of China 2015 M572049 / China Postdoctoral Science Foundation 81401131 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000462156500003
- Scopus ID
- 2-s2.0-85058069726
- Other Identifier
- 991019167537104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Endocrinology & Metabolism
- Neurosciences