Journal article
Neuropathogenesis of human immunodeficiency virus infection
Seminars in the neurosciences, v 3(2), pp 131-139
1991
Abstract
In general, the acquired immunodeficiency syndrome (AIDS) is considered to be a disease of the immune system; however, other organ systems, including the nervous system, are targets of the human immunodeficiency virus (HIV). It is now well established that infection with HIV frequently results in a wide range of degenerative neurological abnormalities affecting the nervous system in many AIDS patients. A wide body of experimental evidence indicates that HIV is present in the nervous system of AIDS patients with neurological complications, thus implicating HIV in the etiology of HIV-associated neurological dysfunction. This may occur either as a result of direct HIV infection of glia and possibly neurons or because of indirect mechanisms mediated by the toxic action of viral or cellular products in the nervous system; however, the exact pathogenic mechanisms leading to HIV-associated neurological dysfunction remain obscure.
Metrics
3 Record Views
6 citations in Scopus
Details
- Title
- Neuropathogenesis of human immunodeficiency virus infection
- Creators
- Maribeth Tillmann - Pennsylvania State UniversityBrian Wigdahl - Pennsylvania State University
- Publication Details
- Seminars in the neurosciences, v 3(2), pp 131-139
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Scopus ID
- 2-s2.0-34347368128
- Other Identifier
- 991020111170404721