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Neuropeptide FF exerts pro- and anti-opioid actions in the parabrachial nucleus to modulate food intake
Journal article   Peer reviewed

Neuropeptide FF exerts pro- and anti-opioid actions in the parabrachial nucleus to modulate food intake

Danielle M Nicklous and Kenny J Simansky
American journal of physiology. Regulatory, integrative and comparative physiology, v 285(5), pp R1046-1054
Nov 2003
DOI: https://doi.org/10.1152/ajpregu.00107.2003
PMID: 14557236

Abstract

Analgesics, Opioid - pharmacology Animals Dose-Response Relationship, Drug Drinking - drug effects Eating - drug effects Enkephalin, Ala-MePhe-Gly- - pharmacology Feeding Behavior - drug effects Hyperphagia - chemically induced Hyperphagia - prevention & control Immunohistochemistry Male Naloxone - pharmacology Narcotic Antagonists - pharmacology Oligopeptides - pharmacology Pons - drug effects Pons - physiology Rats Rats, Sprague-Dawley
Neurons that synthesize the morphine modulatory peptide neuropeptide FF (NPFF; Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2) densely innervate the parabrachial nucleus (PBN), an area implicated in regulating food intake. We analyzed opioid-related actions of NPFF in feeding in adult male Sprague-Dawley rats. Unilateral infusion of 2 nmol/0.5 microl of the mu-opioid receptor agonist [d-Ala2,NMe-Phe4,glycinol5]enkephalin (DAMGO) into the lateral PBN increased 4-h food intake from 0.7 +/- 0.1 to 3.3 +/- 0.3 g. NPFF (1.25-5.0 nmol) prevented this hyperphagic mu-opioidergic action. In rats fed after 4-h deprivation (baseline = 12.3 +/- 0.3 g/2 h), 5 nmol of NPFF did not alter and larger doses (10 and 20 nmol) actually increased food intake (+36, 54%). Twenty nanomoles also elevated intake of freely feeding rats (from 0.7 +/- 0.1 to 5.1 +/- 1.0 g/4 h). The opioid receptor blocker naloxone (10 nmol) antagonized this increase. These data reveal both pro- and anti-opioid actions of NPFF in the PBN to modulate feeding. The mechanisms for the opposite actions of low and high concentrations of this neuropeptide in parabrachial regulation of food intake remain to be determined.

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