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Neuroprotective Properties of Chlorogenic Acid and 4,5-Caffeoylquinic Acid from Brazilian arnica (Lychnophora ericoides) after Acute Retinal Ischemia
Journal article   Open access   Peer reviewed

Neuroprotective Properties of Chlorogenic Acid and 4,5-Caffeoylquinic Acid from Brazilian arnica (Lychnophora ericoides) after Acute Retinal Ischemia

José Luiz Liberato, Marcela Nunes Rosa, Matheus C Romeiro Miranda, João Luís Callegari Lopes, Norberto Peporine Lopes, Leonardo Gobbo-Neto, Andreia C K Fontana and Wagner Ferreira Dos Santos
Planta medica, v 89(2), pp 183-193
Feb 2023
DOI: https://doi.org/10.1055/a-1903-2387
PMID: 36220097
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1903-2387.pdfView
Published, Version of Record (VoR) Open
url
https://doi.org/10.1055/a-1903-2387View
Published, Version of Record (VoR) Open

Abstract

Animals Anti-Inflammatory Agents Arnica Brazil Chlorogenic Acid - pharmacology Chlorogenic Acid - therapeutic use Glaucoma - drug therapy Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Plant Extracts - pharmacology Plant Extracts - therapeutic use Rats Rats, Wistar Retinal Diseases - drug therapy
is a genus of South American flowering plants in the daisy family, popularly known as "Brazilian arnica". It is used in traditional medicine as an anti-inflammatory and analgesic agent, whose active components are derived from chlorogenic acid (CGA) and C-flavonoids. Since the drugs currently used are ineffective to treat glaucoma, agents with antioxidant and anti-inflammatory properties may represent new alternatives in preventing cellular lesions in retinal ischemia. In this study, we report the neuroprotective effects of CGA and 4,5-di- -[E]-caffeoylquinic (CQA) acid, isolated from plants, in a rodent glaucoma model. Wistar rats were administered intravitreally with 10 µg CGA or CGA, and then subjected to acute retinal ischemia (ISC) by increasing intraocular pressure (IPO) for 45 minutes followed (or not) by 15 minutes of reperfusion (I/R). Qualitative and quantitative analyses of neurodegeneration were performed using hematoxylin-eosin or Fluoro-Jade C staining protocols. All retinas submitted to ISC or I/R exhibited matrix disorganization, pyknotic nuclei, and pronounced vacuolization of the cytoplasm in the ganglion cell layer (GCL) and inner nuclear layer (INL). Pretreatment with CGA or CQA resulted in the protection of the retinal layers against matrix disorganization and a reduction in the number of vacuolized cells and pyknotic nuclei. Also, pretreatment with CGA or CQA resulted in a significant reduction in neuronal death in the GCL, the INL, and the outer nuclear layer (ONL) after ischemic insult. Our study demonstrated that CGA and CQA exhibit neuroprotective activities in retinas subjected to ISC and I/R induced by IPO in Wistar rats.

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8 citations in Web of Science
6 citations in Scopus

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Chemistry, Medicinal
Integrative & Complementary Medicine
Pharmacology & Pharmacy
Plant Sciences
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