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Neuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future
Journal article   Open access   Peer reviewed

Neuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future

Yonas E. Geda, Lon S. Schneider, Laura N. Gitlin, David S. Miller, Gwenn S. Smith, Joanne Bell, Jovier Evans, Michael Lee, Anton Porsteinsson, Krista L. Lanctôt, …
Alzheimer's & dementia, v 9(5), pp 602-608
Sep 2013
PMID: 23562430
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1016/j.jalz.2012.12.001View
Published, Version of Record (VoR)Open Access (License Unspecified) Open

Abstract

Agitation/aggression Alzheimer's disease Apathy Behavioral and psychological symptoms of dementia Delusions Dementia Depression Hallucinations Mild behavioral impairment Mild cognitive impairment Neuropsychiatric symptoms Psychosis Sleep disorders
Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) are widespread and disabling. This has been known since Dr. Alois Alzheimer's first case, Frau Auguste D., presented with emotional distress and delusions of infidelity/excessive jealousy, followed by cognitive symptoms. Being cognizant of this, in 2010 the Alzheimer's Association convened a research roundtable on the topic of NPS in AD. A major outcome of the roundtable was the founding of a Professional Interest Area (PIA) within the International Society to Advance Alzheimer's Research and Treatment (ISTAART). The NPS-PIA has prepared a series of documents that are intended to summarize the literature and provide more detailed specific recommendations for NPS research. This overview paper is the first of these living documents that will be updated periodically as the science advances. The overview is followed by syndrome-specific synthetic reviews and recommendations prepared by NPS-PIA workgroups on depression, apathy, sleep, agitation, and psychosis.

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Clinical Neurology
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