Journal article
Neuropsychological Syndromes Associated with Alzheimer's/Vascular Dementia: A Latent Class Analysis
Journal of Alzheimer's disease, v 42(3), pp 999-1014
01 Jan 2014
PMID: 25024329
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Epidemiologic autopsy studies show mixed Alzheimer's disease (AD)/vascular pathology in many patients. Moreover, clinical research shows that it is not uncommon for AD and vascular dementia (VaD) patients to be equally impaired on memory, executive, or other neurocognitive tests. However, this clinical heterogeneity has not been incorporated into the new diagnostic criteria for AD (Dubois et al., 2010; McKhann et al., 2011).
Objective: The current research applied Latent Class Analysis (LCA) to a protocol of six neuropsychological parameters to identify phenotypic subtypes from a large group of AD/VaD participants. Follow-up analyses examined difference between groups on neuroradiological parameters and neuropsychological measures of process and errors.
Methods: 223 AD/VaD patients were administered a comprehensive neuropsychological protocol. Measures of whole brain and hippocampal volume were available for a portion of the sample (n = 76).
Results: LCA identified four distinct groups: moderate/mixed dementia (n = 54; 24.21%), mild/mixed dementia (n = 91; 40.80%); dysexecutive (n = 49, 21.97%), and amnestic (n = 29, 13.00%). Follow-up analyses comparing the groups on neuropsychological process and error scores showed that the dysexecutive group exhibited difficulty sustaining mental set. The moderate/mixed group evidenced pronounced impairment on tests of lexical retrieval/naming along with significant amnesia. Amnestic patients also presented with gross amnesia, but showed relative sparing on other neuropsychological measures. Mild/mixed patients exhibited milder memory deficits that were intermediary between the amnestic and moderate/mixed groups.
Conclusions: There are distinct neuropsychological profiles in patients independent of clinical diagnosis, suggesting that the two are not wholly separate and that this information should be integrated into new AD diagnostic paradigms.
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Details
- Title
- Neuropsychological Syndromes Associated with Alzheimer's/Vascular Dementia: A Latent Class Analysis
- Creators
- David J. Libon - Drexel UniversityDeborah A. G. Drabick - Temple UniversityTania Giovannetti - Temple UniversityCatherine C. Price - University of FloridaMark W. Bondi - VA San Diego Healthcare SystemJoel Eppig - Drexel UniversityKathryn Devlin - Temple UniversityChristine Nieves - Drexel UniversityMelissa Lamar - University of Illinois at ChicagoLisa Delano-Wood - VA San Diego Healthcare SystemDaniel A. Nation - University of Southern CaliforniaLaura Brennan - Drexel UniversityRhoda Au - Framingham Heart StudyRod Swenson - North Dakota State University
- Publication Details
- Journal of Alzheimer's disease, v 42(3), pp 999-1014
- Publisher
- Ios Press
- Number of pages
- 16
- Grant note
- IIRG-06-27542 / Alzheimer's Association K23NS060660 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) K23NS060660 / NINDS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000342237000027
- Scopus ID
- 2-s2.0-84907154006
- Other Identifier
- 991019168542204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences