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Journal article
Neuropsychological patterns in magnetic resonance imaging-defined subgroups of patients with degenerative dementia
Journal of the International Neuropsychological Society, v 15(3), pp 459-470
01 May 2009
PMID: 19402932
Abstract
We hypothesized that specific neuropsychological deficits were associated with specific patterns of atrophy. A magnetic resonance imaging volumetric study and a neuropsychological protocol were obtained for patients with several frontotemporal lobar dementia phenotypes including a social/dysexecutive (SOC/EXEC, n = 17), progressive nonfluent aphasia (n = 9), semantic dementia (n = 7), corticobasal syndrome (it = 9), and Alzheimer's disease (it = 2 1 Blinded to testing results, patients were partitioned according to pattern of predominant cortical atrophy; our partitioning algorithm had been derived using seriation, a hierarchical classification technique. Neuropsychological test scores were regressed versus these atrophy patterns as fixed effects using the covariate total atrophy its marker For disease severity. The results showed the Model accounted For substantial variance. Furthermore, the "large-scale networks" associated with each neuropsychological test conformed well to the known literature. For example, bilateral prefrontal cortical atrophy was exclusively associated with SOC/EXEC dysfunction. The neuropsychological principle Of "double dissociation" was supported not just by Such active associations but also by the "silence" of locations not previously implicated by the literature. WC Conclude that classifying patients with degenerative dementia by specific pattern of cortical atrophy has the potential to predict individual patterns of cognitive deficits. (JINS, 2009, 15 459-470.)
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Details
- Title
- Neuropsychological patterns in magnetic resonance imaging-defined subgroups of patients with degenerative dementia
- Creators
- John Listerud - University of PennsylvaniaChivon Powers - College Station Medical CenterPeachie Moore - College Station Medical CenterDavid J. Libon - Drexel UniversityMurray Grossman - College Station Medical Center
- Publication Details
- Journal of the International Neuropsychological Society, v 15(3), pp 459-470
- Publisher
- Cambridge Univ Press
- Number of pages
- 12
- Grant note
- P01AG017586 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) NS44266; P50 NS053488-040002; R01 NS044266; R01 NS044266-07; P50 NS053488 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) P50NS053488 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) AG15116; P01 AG017586-100001; AG17586; R01 AG015116-12; R01 AG015116; P01 AG017586 / NIA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000266066700014
- Scopus ID
- 2-s2.0-67651152993
- Other Identifier
- 991021901313704721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences
- Psychiatry
- Psychology