Journal article
New Insights into Classical Costimulation of CD8+T Cell Responses
CROSSROADS BETWEEN INNATE AND ADAPTIVE IMMUNITY II, v 633, pp 91-111
01 Jan 2009
PMID: 19209684
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Nearly 40 years ago a theory was put forth postulating that an immune cell must receive two signals during activation to discriminate self- from nonself-antigen. One signal must be through an antigen-specific receptor and the second signal must be through a costimulatory receptor which would indicate that the antigen was indeed foreign and that a response was required. This theory came to be known as the two signal theory and was long accepted as a key paradigm of immunology. Since its inception, it has sparked a wildfire of research in pursuit of the identification and characterization of such second signal molecules. Today, more than ten costimulatory signals have been identified, both stimulatory and inhibitory, and a multiple signal model has replaced the oversimplified two-signal theory. Here, we will provide an introduction to the members of the classical CD28 family, with a primary focus on
CD28. We will review the function of classical CD28 costimulation in the generation of primary and memory antiviral CD8+ T cell responses. Particular emphasis will be placed on understanding the contribution of CD28 costimulation to efficient antiviral CD8+ T cell memory responses. Until recently, the importance of CD28 signaling in such memory CD8+ T cell responses has remained unappreciated. Finally, we will discuss the implications of these new insights into the role of CD28 as they relate to the future of vaccine design, tumor suppression, and autoimmunity.
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Details
- Title
- New Insights into Classical Costimulation of CD8+T Cell Responses
- Creators
- Christine M. Bucks - Drexel UniversityPeter D Katsikis - Drexel University
- Publication Details
- CROSSROADS BETWEEN INNATE AND ADAPTIVE IMMUNITY II, v 633, pp 91-111
- Series
- Advances in Experimental Medicine and Biology
- Publisher
- Springer Nature
- Number of pages
- 21
- Grant note
- R01 AI62437; R01 AI66215; R01 AI46719 / NIAID NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) R01AI066215 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000261373100009
- Scopus ID
- 2-s2.0-65349166713
- Other Identifier
- 9780387793115; 0387793119; 991019348910804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Medicine, Research & Experimental