Journal article
New advances in measurement of complement activation: lessons of systemic lupus erythematosus
Current rheumatology reports, v 6(5), pp 375-381
Oct 2004
PMID: 15355750
Abstract
Activation of the complement system plays a fundamental role in the pathogenesis of systemic lupus erythematosus (SLE). For the past several decades, quantifying this process has focused primarily on determination of serum C3 and C4, although the utility of these assays for diagnosis and monitoring disease activity is still debated. During this same timespan, knowledge of the complement system has exploded, with identification of more than 30 proteins, an abundance of newly recognized functions, and even a third pathway of activation. These advances suggest that it is appropriate to revisit the complement system as a potential source of biomarkers for SLE. This paper reviews briefly the role of complement in SLE and other inflammatory diseases, discusses conventional methods for complement measurement and their drawbacks, and focuses on recent advancements in harnessing the complement system for monitoring SLE. Specifically, novel assays that measure cell-bound complement activation products are introduced and their utility as biomarkers of SLE disease activity is discussed.
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23 citations in Scopus
Details
- Title
- New advances in measurement of complement activation: lessons of systemic lupus erythematosus
- Creators
- Chau-Ching Liu - University of PittsburghSusan ManziNatalya DanchenkoJoseph M Ahearn - University of Pittsburgh
- Publication Details
- Current rheumatology reports, v 6(5), pp 375-381
- Publisher
- Springer Nature
- Grant note
- P30 AR-47372 / NIAMS NIH HHS M01-RR-00056 / NCRR NIH HHS R01 AR-46588 / NIAMS NIH HHS R01 HL-074335 / NHLBI NIH HHS K24 AR-02213 / NIAMS NIH HHS R01 AR-4676402 / NIAMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate); General Internal Medicine
- Scopus ID
- 2-s2.0-16544375948
- Other Identifier
- 991021934011204721