Journal article
New evidence for a gating action of norepinephrine in central neuronal circuits of mammalian brain
Brain research bulletin, v 21(3), pp 425-432
1988
PMID: 3214748
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Many previous studies have examined the effects of norepinephrine (NE) on neuronal responsiveness to synaptic inputs and putative transmitter substances and have described differential depressant actions of NE on stimulus evoked versus spontaneous discharge such that the “signal to noise” ratio of threshold responses was increased. In the present studies, similar experimental strategies employing a combination of microiontophoresis, single unit recording and afferent pathway stimulation in intact anesthetized and brain tissue slice preparations have revealed noradrenergic “gating” actions whereby weak or subthreshold synaptic stimuli can evoke threshold neuronal responses in the presence of iontophoretically applied NE or following electrical stimulation of the locus coeruleus. Overall, these results suggest that potentially threshold excitatory and inhibitory synaptic inputs may normally arrive at central neurons but appear weak or absent except during behavioral conditions favoring the synaptic release of NE. As such, these findings provide evidence that signal to noise ratio may not be the only potential modulatory action expressed by NE in noradrenergic target circuits of the mammalian brain.
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Details
- Title
- New evidence for a gating action of norepinephrine in central neuronal circuits of mammalian brain
- Creators
- Barry D WaterhouseFrancis M SesslerCheng Jung-TungDonald J WoodwardS.Ausim AziziHylan C Moises
- Publication Details
- Brain research bulletin, v 21(3), pp 425-432
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; [Retired Faculty]
- Web of Science ID
- WOS:A1988R001100010
- Scopus ID
- 2-s2.0-0024157855
- Other Identifier
- 991014878538104721
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- Web of Science research areas
- Neurosciences