Journal article
New evidence for neurotransmitter influences on brain development
Trends in neurosciences (Regular ed.), v 20(6), pp 269-274
1997
PMID: 9185309
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The early appearance of monoamine systems in the developing mammalian CNS suggests that they play a role in neural development. We review data from two model systems that provide compelling new evidence of this role. In one model system –
in utero exposure to cocaine – specific and robust alterations are seen in dopamine-rich areas of the cerebral cortex, such as the anterior cingulate cortex: D
1 receptor–G protein coupling is greatly reduced, the GABAergic system is altered and pyramidal dendrites undergo excessive growth. In a second model system – a transgenic mouse line in which the gene that encodes monoamine oxidase A (MAOA) is disrupted, resulting in excessively high 5-HT levels – barrels fail to form in the developing somatosensory cortex. Both models reveal the effects of very early manipulation of monoamines on forebrain development, and the long-term anomalies that persist into adulthood.
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Details
- Title
- New evidence for neurotransmitter influences on brain development
- Creators
- Pat Levitt - Dept of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USAJohn A Harvey - Dept of Pharmacology, MCPuHahneman School of Medicine, Allegheny University of the Health Sciences, Philadelphia, PA 19129, USAEitan Friedman - Dept of Pharmacology, MCPuHahneman School of Medicine, Allegheny University of the Health Sciences, Philadelphia, PA 19129, USAKenny Simansky - Dept of Pharmacology, MCPuHahneman School of Medicine, Allegheny University of the Health Sciences, Philadelphia, PA 19129, USAE.Hazel Murphy - Dept of Neurobiology and Anatomy, MCPuHahneman School of Medicine, Allegheny University of the Health Sciences, Philadelphia, PA 19129, USA
- Publication Details
- Trends in neurosciences (Regular ed.), v 20(6), pp 269-274
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; Pharmacology and Physiology
- Web of Science ID
- WOS:A1997XC44700010
- Scopus ID
- 2-s2.0-0031172430
- Other Identifier
- 991014878053304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences