Journal article
New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice
The Journal of immunology (1950), v 161(4), pp 1860-1867
15 Aug 1998
PMID: 9712054
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Experimental allergic encephalomyelitis (EAE), the principal animal model of multiple sclerosis, is a genetically determined phenotype. In this study, analyses of the cumulative disease frequencies in parental, F1 hybrid, and F2 mice, derived from the EAE-susceptible SJL/J strain and the EAE-resistant B10.S/DvTe strain, confirmed that susceptibility to EAE is not inherited as a simple Mendelian trait. Whole genome scanning, using 150 informative microsatellite markers and a panel of 291 affected and 390 unaffected F2 progeny, revealed significant linkage of EAE susceptibility to marker loci on chromosomes 7 (eae4) and 17, distal to H2 (eae5). Quantitative trait loci for EAE severity, duration, and onset were identified on chromosomes 11 (eae6, and eae7), 2 (eae8), 9 (eae9), and 3 (eae10). While each locus reported in this study is important in susceptibility or disease course, interactions between marker loci were not statistically significant in models of genetic control. One locus, eae7, colocalizes to the same region of chromosome II as Orch3 and Idd4, susceptibility loci in autoimmune orchitis and insulin-dependent diabetes mellitus, respectively. Importantly, eae5 and eae7 are syntenic with human chromosomes 6p21 and 17q22, respectively, two regions of potential significance recently identified in human multiple sclerosis genome scans.
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Details
- Title
- New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice
- Creators
- R J Butterfield - Department of Veterinary Pathobiology, University of Illinois, Urbana 61802, USAJ D SudweeksE P BlankenhornR KorngoldJ C MariniJ A ToddR J RoperC Teuscher
- Publication Details
- The Journal of immunology (1950), v 161(4), pp 1860-1867
- Publisher
- United States
- Grant note
- HD27275 / NICHD NIH HHS Wellcome Trust HD21926 / NICHD NIH HHS NS33588 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000075345400037
- Scopus ID
- 2-s2.0-0032529630
- Other Identifier
- 991014878124804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology