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Accepted (AM)Open Access (License Unspecified), Open
Journal article
New insights in the mechanisms of weight‐loss maintenance: Summary from a Pennington symposium
Obesity (Silver Spring, Md.)
16 Oct 2023
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Abstract Obesity is a chronic disease that affects more than 650 million adults worldwide. Obesity not only is a significant health concern on its own, but predisposes to cardiometabolic comorbidities, including coronary heart disease, dyslipidemia, hypertension, type 2 diabetes, and some cancers. Lifestyle interventions effectively promote weight loss of 5% to 10%, and pharmacological and surgical interventions even more, with some novel approved drugs inducing up to an average of 25% weight loss. Yet, maintaining weight loss over the long‐term remains extremely challenging, and subsequent weight gain is typical. The mechanisms underlying weight regain remain to be fully elucidated. The purpose of this Pennington Biomedical Scientific Symposium was to review and highlight the complex interplay between the physiological, behavioral, and environmental systems controlling energy intake and expenditure. Each of these contributions were further discussed in the context of weight‐loss maintenance, and systems‐level viewpoints were highlighted to interpret gaps in current approaches. The invited speakers built upon the science of obesity and weight loss to collectively propose future research directions that will aid in revealing the complicated mechanisms involved in the weight‐reduced state.
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Details
- Title
- New insights in the mechanisms of weight‐loss maintenance: Summary from a Pennington symposium
- Creators
- Emily W. Flanagan - Pennington Biomedical Research CenterRedin Spann - Pennington Biomedical Research CenterSarah E. Berry - King's College LondonHans‐Rudolf Berthoud - Pennington Biomedical Research CenterStephanie Broyles - Pennington Biomedical Research CenterGary D. Foster - University of PennsylvaniaJonathan Krakoff - Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology & Clinical Research Branch, NIDDK‐Phoenix Phoenix Arizona USARuth J. F. Loos - Novo Nordisk FoundationMichael R. Lowe - Drexel UniversityDanielle M. Ostendorf - University of Colorado Anschutz Medical CampusTiffany M. Powell-Wiley - National Institute on Minority Health and Health DisparitiesLeanne M. Redman - Pennington Biomedical Research CenterMichael Rosenbaum - Columbia University Irving Medical CenterPhilip R. Schauer - Pennington Biomedical Research CenterRandy J. Seeley - University of MichiganBoyd A. Swinburn - University of AucklandKevin Hall - National Institute of Diabetes and Digestive and Kidney DiseasesEric Ravussin - Pennington Biomedical Research Center
- Publication Details
- Obesity (Silver Spring, Md.)
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:001085152800001
- Scopus ID
- 2-s2.0-85174230734
- Other Identifier
- 991021455305204721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Endocrinology & Metabolism
- Nutrition & Dietetics