Journal article
New job for an old tool: PI3Kβ phosphorylates OGT to regulate acetyl-CoA in glioblastoma
Trends in cell biology, v 35(5), pp 361-363
01 May 2025
PMID: 40246630
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta (PI3Kβ) is recognized for its role in cellular signaling as a lipid kinase. He and colleagues recently reported a non-canonical function of PI3Kβ where, under high glucose, it phosphorylates and activates O-GlcNAc transferase (OGT). This activation enhances ATP-citrate synthase (ACLY) O-GlcNAcylation, increasing acetyl-CoA production, fueling fatty acid metabolism and histone acetylation, and driving glioblastoma (GBM) growth.
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta (PI3Kβ) is recognized for its role in cellular signaling as a lipid kinase. He and colleagues recently reported a non-canonical function of PI3Kβ where, under high glucose, it phosphorylates and activates O-GlcNAc transferase (OGT). This activation enhances ATP-citrate synthase (ACLY) O-GlcNAcylation, increasing acetyl-CoA production, fueling fatty acid metabolism and histone acetylation, and driving glioblastoma (GBM) growth.
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Details
- Title
- New job for an old tool: PI3Kβ phosphorylates OGT to regulate acetyl-CoA in glioblastoma
- Creators
- Riley G. Young - Drexel University, Biochemistry and Molecular BiologyNusaiba N. Ahmed - Drexel University, College of MedicineMauricio J. Reginato - Drexel University, Biochemistry and Molecular Biology
- Publication Details
- Trends in cell biology, v 35(5), pp 361-363
- Publisher
- Elsevier Ltd
- Number of pages
- 3
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; College of Medicine
- Web of Science ID
- WOS:001500862700001
- Scopus ID
- 2-s2.0-105003464534
- Other Identifier
- 991022048295204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology