Journal article
New links between lipid accumulation and cancer progression
The Journal of biological chemistry, v 293(17), pp 6635-6636
27 Apr 2018
PMID: 29703762
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Individuals with elevated lipid levels are at risk for developing cardiovascular disease as well as cancer. Sterol regulatory element–binding protein transcription factors (SREBPs) are inducers of lipid synthesis. Elevated SREBPs levels are linked to cell proliferation and metastasis. Using biochemical and mouse models of cancer, Zhao et al. have discovered that nuclear SREBP-1a–dependent transcription is activated by pyruvate kinase M2 in cancer cells, which promotes tumor growth. Targeting the lipogenesis pathway may therefore be a promising avenue for cancer treatment.
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Details
- Title
- New links between lipid accumulation and cancer progression
- Creators
- Joseph T. Nickels - Ansys
- Publication Details
- The Journal of biological chemistry, v 293(17), pp 6635-6636
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000431108600033
- Scopus ID
- 2-s2.0-85046028609
- Other Identifier
- 991021230008804721
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- Web of Science research areas
- Biochemistry & Molecular Biology