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Journal article
Nitric Oxide Has a Vasodilatory Role in Cat Optic Nerve Head during Flicker Stimuli
Microvascular research, v 52(1), pp 13-26
Jul 1996
PMID: 8812749
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Abstract
The role of nitric oxide (NO) in the regulation of optic nerve head (ONH) blood flow was investigated from direct electrochemical measurements of NO and simultaneous measurements of ONH blood flow by laser Doppler flowmetry during increased neuronal activity with diffuse luminance flickering light stimuli. For normal physiological conditions, there was a consistent increase in ONH blood flow with each flicker stimulus (n= 10 cats). Simultaneous NO measurements were made in the vitreous humor immediately in front of the ONH (n= 6 cats). During flicker, NO increased by 88 ± 23 nM(P< 0.05) above basal NO levels. Measurements were repeated after inhibiting NO synthase by intravenous infusion of either NG-nitro-L-arginine (n= 5 cats) or NG-nitro-L-arginine methyl ester (n= 5 cats). After inhibition, NO levels were significantly reduced and both ONH blood flow and NO responses to flicker were significantly attenuated. We conclude that NO plays a key vasodilatory role in the ONH, modulating blood flow during greater neuronal activity with flicker stimuli.
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Details
- Title
- Nitric Oxide Has a Vasodilatory Role in Cat Optic Nerve Head during Flicker Stimuli
- Creators
- Donald G. Buerk - University of PennsylvaniaCharles E. Riva - Penn Presbyterian Medical CenterStephen D. Cranstoun - Penn Presbyterian Medical Center
- Publication Details
- Microvascular research, v 52(1), pp 13-26
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:A1996UW56000002
- Scopus ID
- 2-s2.0-0030200913
- Other Identifier
- 991019231737704721
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- Web of Science research areas
- Peripheral Vascular Disease