Journal article
Nitric Oxide Synthase Inhibition Depresses the Height of the Cerebral Blood Flow–Pressure Autoregulation Curve during Moderate Hypotension
Journal of cerebral blood flow and metabolism, v 23(9), pp 1085-1095
Sep 2003
PMID: 12973025
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Variations in the height of the CBF response to hypotension have been described recently in normal animals. The authors evaluated the effects of nitric oxide synthase (NOS) inhibition on these variations in height using laser Doppler flowmetry in 42 anesthetized (halothane and N
2
O) male Sprague-Dawley rats prepared with a superfused closed cranial window. In four groups (time control, enantiomer control, NOS inhibition, and reinfusion control) exsanguination to MABPs from 100 to 40 mm Hg was used to produce autoregulatory curves. For each curve the lower limit of autoregulation (the MABP at the first decrease in CBF) was identified; the pattern of autoregulation was classified as “peak” (15% increase in %CBF), “classic” (plateau with a decrease at the lower limit of autoregulation), or “none” (15% decrease in %CBF); and the autoregulatory height as the %CBF at 70 mm Hg (%CBF
70
) was determined. NOS inhibition decreased %CBF
70
in the NOS inhibition group (P = 0.014), in the control (combined time and enantiomer control) group (P = 0.015), and in the reinfusion control group (P = 0.025). NOS inhibition via superfusion depressed the autoregulatory pattern (P = 0.02, McNemar test on changes in autoregulatory pattern) compared with control (P = 0.375). Analysis of covariance showed that changes induced by NOS inhibition in the parameters of autoregulatory height are not related to changes in the lower limit, but are strongly (P < 0.001) related to each other. NOS inhibition depressed the autoregulatory pattern, decreasing the seemingly paradoxical increase in CBF as blood pressure decreases. These results suggest that nitric oxide increases CBF near the lower limit and augments the hypotensive portion of the autoregulatory curve.
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Details
- Title
- Nitric Oxide Synthase Inhibition Depresses the Height of the Cerebral Blood Flow–Pressure Autoregulation Curve during Moderate Hypotension
- Creators
- Stephen C. Jones - Drexel UniversityKirk A. Easley - Emory UniversityCarol R. Radinsky - Ross University School of Veterinary MedicineDouglas Chyatte - Drexel UniversityAnthony J. Furlan - Cleveland ClinicAlejandro D. Perez-Trepichio - Cleveland Clinic Florida
- Publication Details
- Journal of cerebral blood flow and metabolism, v 23(9), pp 1085-1095
- Publisher
- Lippincott
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Anesthesiology and Perioperative Medicine
- Web of Science ID
- WOS:000185144800010
- Scopus ID
- 2-s2.0-0042337115
- Other Identifier
- 991019167441504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Endocrinology & Metabolism
- Hematology
- Neurosciences