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Nitric oxide-mediated Ca 2+/calmodulin-dependent protein kinase IV activity during hypoxia in neuronal nuclei from newborn piglets
Journal article   Peer reviewed

Nitric oxide-mediated Ca 2+/calmodulin-dependent protein kinase IV activity during hypoxia in neuronal nuclei from newborn piglets

Alan B Zubrow, Maria Delivoria-Papadopoulos, Qazi M Ashraf, Karen I Fritz and Om P Mishra
Neuroscience letters, v 335(1), pp 5-8
2002
DOI: https://doi.org/10.1016/S0304-3940(02)01138-2
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Brain Ca 2+/calmodulin-dependent protein kinase IV Hypoxia N-nitro- L-arginine Nitric oxide Nitric oxide synthase
The present study tested the hypothesis that hypoxia results in increased Ca 2+/calmodulin-dependent protein kinase IV (CaM kinase IV) activity and that inhibition of nitric oxide (NO) synthase by N-nitro- L-arginine (NNLA) prevents the hypoxia- induced increase in neuronal nuclear CaM kinase IV activity in newborn piglets. CaM kinase IV activity was determined in normoxic (Nx), hypoxic (Hx), and NNLA-pretreated Hx piglets. Cerebral hypoxia was confirmed biochemically. There was a significant difference between CaM kinase IV activity (pmoles/mg protein/min) in Nx (285.22±86.12), Hx (494.77±99.79, P<0.05 vs. Nx), and NNLA-pretreated Hx (249.55±53.85)( P=NS vs. Nx, P<0.05 vs. Hx) animals. The results demonstrate that the cerebral tissue hypoxia results in an increase in neuronal nuclear CaM kinase IV activity, and the hypoxia-induced increase in CaM kinase IV activity is NO-mediated.

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