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Nitric oxide release by deoxymyoglobin nitrite reduction during cardiac ischemia: A mathematical model
Journal article   Open access   Peer reviewed

Nitric oxide release by deoxymyoglobin nitrite reduction during cardiac ischemia: A mathematical model

Yien Liu, Donald G Buerk, Kenneth A Barbee and Dov Jaron
Microvascular research, v 112, pp 79-86
Jul 2017
DOI: https://doi.org/10.1016/j.mvr.2017.03.009
PMID: 28363495
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc5500307View
Accepted (AM) Open Open Access (License Unspecified)

Abstract

Animals Arterioles - physiopathology Blood Flow Velocity Cell Hypoxia Computer Simulation Coronary Circulation Humans Hydrogen-Ion Concentration Models, Cardiovascular Myocardial Ischemia - blood Myocardial Ischemia - metabolism Myocardial Ischemia - physiopathology Myocardium - metabolism Myoglobin - metabolism Nitric Oxide - metabolism Nitrites - metabolism Numerical Analysis, Computer-Assisted Oxidation-Reduction Oxygen - blood Regional Blood Flow
Interactions between cardiac myoglobin (Mb), nitrite, and nitric oxide (NO) are vital in regulating O storage, transport, and NO homeostasis. Production of NO through the reduction of endogenous myocardial nitrite by deoxygenated myoglobin has been shown to significantly reduce myocardial infarction damage and ischemic injury. We developed a mathematical model for a cardiac arteriole and surrounding myocardium to examine the hypothesis that myoglobin switches functions from being a strong NO scavenger to an NO producer via the deoxymyoglobin nitrite reductase pathway. Our results predict that under ischemic conditions of flow, blood oxygen level, and tissue pH, deoxyMb nitrite reduction significantly elevates tissue and smooth muscle cell NO. The size of the effect is consistent at different flow rates, increases with decreasing blood oxygen and tissue pH and, in extreme pathophysiological conditions, NO can even be elevated above the normoxic levels. Our simulations suggest that cardiac deoxyMb nitrite reduction is a plausible mechanism for preserving or enhancing NO levels using endogenous nitrite despite the rate-limiting O levels for endothelial NO production. This NO could then be responsible for mitigating deleterious effects under ischemic conditions.

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Peripheral Vascular Disease
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