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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Nitric oxide signaling in the microcirculation
Critical reviews in biomedical engineering, v 39(5), pp 397-433
2011
PMID: 22196161
Abstract
Several apparent paradoxes are evident when one compares mathematical predictions from models of nitric oxide (NO) diffusion and convection in vasculature structures with experimental measurements of NO (or related metabolites) in animal and human studies. Values for NO predicted from mathematical models are generally much lower than in vivo NO values reported in the literature for experiments, specifically with NO microelectrodes positioned at perivascular locations next to different sizes of blood vessels in the microcirculation and NO electrodes inserted into a wide range of tissues supplied by the microcirculation of each specific organ system under investigation. There continues to be uncertainty about the roles of NO scavenging by hemoglobin versus a storage function that may conserve NO, and other signaling targets for NO need to be considered. This review describes model predictions and relevant experimental data with respect to several signaling pathways in the microcirculation that involve NO.
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30 citations in Scopus
Details
- Title
- Nitric oxide signaling in the microcirculation
- Creators
- Donald G Buerk - Drexel University, Philadelphia, PA, USAKenneth A BarbeeDov Jaron
- Publication Details
- Critical reviews in biomedical engineering, v 39(5), pp 397-433
- Publisher
- United States
- Grant note
- R01 HL068164 / NHLBI NIH HHS HL068164 / NHLBI NIH HHS U01 HL116256 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; [Retired Faculty]
- Scopus ID
- 2-s2.0-79959892133
- Other Identifier
- 991014878428804721