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No association between marker and Alzheimer's disease
Journal article   Open access   Peer reviewed

No association between marker and Alzheimer's disease

Aleister J Saunders
Molecular psychiatry, v 8(6), pp 571-573
2003
DOI: https://doi.org/10.1038/sj.mp.4001355
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1038/sj.mp.4001355View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

SIR – Recently, three studies reported genetic association of an anonymous microsatellite marker on chromosome 10p12 (D10S1423) and Alzheimer's disease (AD),1,2,3 whereas a fourth study failed to replicate these findings4. At least four linkage studies have implicated regions on chromosome 10 as likely to harbor an AD susceptibility gene5,6,7,8; however, all reported linkage peaks map considerably distal to D10S1423 (>40 cM). In an attempt to clarify these conflicting results, we have tested D10S1423 as well as two adjacent markers (D10S2325 and D10S1426) for association with AD in a large and well characterized sample of multiplex AD families using family-based methodologies. Our results show no evidence of association between any of these markers and disease phenotype, neither in the sample as a whole nor in subsamples stratified by APOE ɛ4-genotype or onset age. These negative findings are consistent with linkage analyses performed on the same sample5 and also with other independent linkage studies,6,7,8 suggesting that the putative chromosome 10 AD gene(s) is located considerably further distal (q-ter).

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Web of Science research areas
Biochemistry & Molecular Biology
Neurosciences
Psychiatry
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