Journal article
Nocturnal Enuresis: A Suggestive Endophenotype Marker for a Subgroup of Inattentive Attention-Deficit/Hyperactivity Disorder
The Journal of pediatrics, v 155(2)
01 Aug 2009
PMID: 19446845
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective Attention-deficit/hyperactivity disorder (ADHD) and enuresis co-occur at a higher rate than expected; the cause for this is unclear.
Study design Diagnostic and demographic variables were compared in 344 children ages 6 to 12 years, with and without enuresis, recruited in an ADHD genetic study. Sleep variables were investigated in a subgroup of 44 enuretic children with age- and sex-matched nonenuretic controls. The association of enuresis with single nucleotide polymorphisms located in regions reported in linkage with enuresis was explored.
Results The prevalence rate of nocturnal enuresis was 16.9% for the entire cohort. There were no differences in sex, age, socioeconomic status, intelligence quotient, medication treatment, or comorbidities. The enuresis group had a higher likelihood of inattentive symptoms than the nonenuretic group. Night wakings and ability of children to wake themselves in the morning were both significantly decreased in children with enuresis compared with control children in the Child Sleep Habits Questionnaire Night Wakings subscale. No significant association was found with chromosomal regions previously reported in linkage with enuresis.
Conclusions Deficits in arousal may contribute to both enuresis and inattentive ADHD. Nocturnal enuresis may be a useful clinical marker in identifying a subgroup of the inattentive phenotype in ADHD genetic studies. (J Pediatr 2009; 155:239-44).
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Details
- Title
- Nocturnal Enuresis: A Suggestive Endophenotype Marker for a Subgroup of Inattentive Attention-Deficit/Hyperactivity Disorder
- Creators
- Josephine Elia - Children's Hospital of PhiladelphiaToshinobu Takeda - Children's Hospital of PhiladelphiaRachel Deberardinis - University of Pennsylvania, Philadelphia PA.Judy Burke - Children's Hospital of PhiladelphiaJennifer Accardo - Children's Hospital of PhiladelphiaPaul J. Ambrosini - Drexel UniversityNathan J. Blum - Children's Hospital of PhiladelphiaLawrence W. Brown - Children's Hospital of PhiladelphiaFrancesca Lantieri - Children's Hospital of PhiladelphiaWade Berrettini - University of Pennsylvania, Philadelphia PA.Marcella Devoto - Children's Hospital of PhiladelphiaHakon Hakonarson - Children's Hospital of Philadelphia
- Publication Details
- The Journal of pediatrics, v 155(2)
- Publisher
- Elsevier
- Number of pages
- 6
- Grant note
- UL1-RR-024134 / NCRR NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) K23MH066275 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) K23MH066275-01 / NIMH NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) UL1RR024134 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000268781200021
- Scopus ID
- 2-s2.0-67651097858
- Other Identifier
- 991019167871804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pediatrics