Journal article
Non-Hodgkin’s lymphoma in systemic lupus erythematosus
Annals of the rheumatic diseases, v 64(10), pp 1507-1509
01 Oct 2005
PMID: 16162903
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Recent evidence supports an association between systemic lupus erythematosus (SLE) and non-Hodgkin’s lymphoma (NHL). Objectives: To describe demographic factors, subtypes, and survival of patients with SLE who develop NHL. Methods: A multi-site cohort of 9547 subjects with definite SLE was assembled. Subjects at each centre were linked to regional tumour registries to determine cancer cases occurring after SLE diagnosis. For the NHL cases ascertained, descriptive statistics were calculated, and NHL subtype frequency and median survival time of patients determined. Results: 42 cases of NHL occurred in the patients with SLE during the 76 948 patient-years of observation. The median age of patients at NHL diagnosis was 57 years. Thirty six (86%) of the 42 patients developing NHL were women, reflecting the female predominance of the cohort. In the patients, aggressive histological subtypes appeared to predominate, with the most commonly identified NHL subtype being diffuse large B cell (11 out of 21 cases for which histological subtype was available). Twenty two of the patients had died a median of 1.2 years after lymphoma diagnosis. Conclusions: These data suggest aggressive disease in patients with SLE who develop NHL. Continuing work should provide further insight into the patterns of presentation, prognosis, and aetiology of NHL in SLE.
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Details
- Title
- Non-Hodgkin’s lymphoma in systemic lupus erythematosus
- Creators
- S Bernatsky - Montreal General HospitalR Ramsey-Goldman - Northwestern UniversityR Rajan - Montreal General HospitalJ-F Boivin - McGill UniversityL Joseph - Montreal General HospitalS Lachance - Montreal General HospitalD Cournoyer - Montreal General HospitalA Zoma - Hairmyres HospitalS Manzi - University of Pittsburgh School of MedicineE Ginzler - SUNY Downstate Health Sciences UniversityM Urowitz - University of TorontoD Gladman - University of TorontoP R Fortin - University of TorontoS Edworthy - University of CalgaryS Barr - University of CalgaryC Gordon - University of BirminghamS-C Bae - Hanyang UniversityJ Sibley - Department of Rheumatology, Royal University Hospital, Saskatoon, SK, CanadaK SteinssonO Nived - Department of Rheumatology, University Hospital, Lund, SwedenG Sturfelt - Department of Rheumatology, University Hospital, Lund, SwedenY St Pierre - Montreal General HospitalA Clarke - Montreal General Hospital
- Publication Details
- Annals of the rheumatic diseases, v 64(10), pp 1507-1509
- Publisher
- BMJ Publishing Group Ltd and European League Against Rheumatism
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000231875800024
- Scopus ID
- 2-s2.0-27744486101
- Other Identifier
- 991021934002604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology