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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Non-Invasive Intra-cardiac Pressure Measurements Using Subharmonic-Aided Pressure Estimation: Proof of Concept in Humans
Ultrasound in medicine & biology, v 43(11), pp 2718-2724
Nov 2017
PMID: 28807449
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study evaluated the feasibility of employing non-invasive intra-cardiac pressure estimation using subharmonic signals from ultrasound contrast agents in humans. This institutional review board-approved proof-of-concept study included 15 consenting patients scheduled for left and right heart catheterization. During the catheterization procedure, Definity was infused intra-venously at 4-10 mL/min. Ultrasound scanning was performed with a Sonix RP using pulse inversion, three incident acoustic output levels and 2.5-MHz transmit frequency. Radiofrequency data were processed and subharmonic amplitudes were compared with the pressure catheter data. The correlation coefficient between subharmonic signals and pressure catheter data ranged from -0.3 to -0.9. For acquisitions with optimum acoustic output, pressure errors between the subharmonic technique and catheter were as low as 2.6 mmHg. However, automatically determining optimum acoustic output during scanning for each patient remains to be addressed before clinical applicability can be decided.
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Details
- Title
- Non-Invasive Intra-cardiac Pressure Measurements Using Subharmonic-Aided Pressure Estimation: Proof of Concept in Humans
- Creators
- Jaydev K Dave - Thomas Jefferson UniversitySushmita V Kulkarni - Drexel UniversityPurva P Pangaonkar - Thomas Jefferson UniversityMaria Stanczak - Thomas Jefferson UniversityMaureen E McDonald - Thomas Jefferson UniversityIra S Cohen - Thomas Jefferson UniversityPraveen Mehrotra - Thomas Jefferson UniversityMichael P Savage - Thomas Jefferson UniversityPaul Walinsky - Thomas Jefferson UniversityNicholas J Ruggiero, 2nd - Thomas Jefferson UniversityDavid L Fischman - Thomas Jefferson UniversityDavid Ogilby - Thomas Jefferson UniversityCarolyn VanWhy - Thomas Jefferson UniversityMatthew Lombardi - Thomas Jefferson UniversityFlemming Forsberg - Thomas Jefferson University
- Publication Details
- Ultrasound in medicine & biology, v 43(11), pp 2718-2724
- Publisher
- Elsevier
- Grant note
- R21 HL130899 / NHLBI NIH HHS R21 HL081892 / NHLBI NIH HHS RC1 DK087365 / NIDDK NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000414739700023
- Scopus ID
- 2-s2.0-85028318090
- Other Identifier
- 991019350590804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging