Journal article
Non-Macrocyclic Schiff Base Complexes of Iron(II) as ParaCEST Agents for MRI
European journal of inorganic chemistry, v 2019(19), pp 2404-2411
26 May 2019
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Nearly two decades of research efforts have been devoted to paramagnetic chemical exchange saturation transfer (paraCEST) to produce image contrast in magnetic resonance imaging. Less than twenty iron-based paraCEST agents have been reported so far, the majority of which are ligated by macrocyclic chelates. In the work presented here three isostructural tripodal ligands sharing a common tris-(aza-butenyl)amine foundation are explored to further diversify iron-based paraCEST agents. One of the complexes provides contrast with a CEST effect of 33 % for a 10 mm sample, a paramagnetic shift (Delta omega) of 85 ppm from bulk H2O, and exhibits some stability to biologically relevant ions.
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Details
- Title
- Non-Macrocyclic Schiff Base Complexes of Iron(II) as ParaCEST Agents for MRI
- Creators
- Jeremiah J. Scepaniak - Drexel UniversityEun Byoung Kang - Drexel UniversityMichael John - University of GöttingenWerner Kaminsky - University of WashingtonSebastian Dechert - University of GöttingenFranc Meyer - University of Göttingen
- Publication Details
- European journal of inorganic chemistry, v 2019(19), pp 2404-2411
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- Spectroscopy Society of Pittsburgh
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:000468964200003
- Scopus ID
- 2-s2.0-85065647003
- Other Identifier
- 991019168624604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Inorganic & Nuclear