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Journal article
Non-Thermal Plasma as a Novel Strategy for Treating or Preventing Viral Infection and Associated Disease
Frontiers in physics, v 9
01 Jun 2021
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Pathogenic viruses cause many human, animal, and plant diseases that are associated with substantial morbidity, mortality and socio-economic impact. Although effective strategies for combatting virus transmission and associated disease are available, global outbreaks of viral pathogens such as the virus responsible for the COVID-19 pandemic demonstrate that there is still a critical need for new approaches that can be used to interrupt the chain of viral infection and mitigate virus-associated pathogenesis. Recent studies point to non-thermal plasma (NTP), a partly ionized gas comprised of a complex mixture of reactive oxygen and nitrogen species along with physical effectors, as the potential foundation for new antiviral approaches. A more thorough understanding of the antiviral properties and safety of NTP has stimulated explorations of NTP as the basis for treatments of viral diseases. The recently described immunomodulatory properties of NTP are also being evaluated for potential use in immunotherapies of viral diseases as well as in antiviral vaccination strategies. In this review, we present the current state-of-the-art in addition to compelling arguments that NTP merits further exploration for use in the prevention and management of viral infections and associated diseases.
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Details
- Title
- Non-Thermal Plasma as a Novel Strategy for Treating or Preventing Viral Infection and Associated Disease
- Creators
- Hager Mohamed - Drexel UniversityGaurav Nayak - Univ Minnesota, Dept Mech Engn, Coll Sci & Engn, 111 Church St SE, Minneapolis, MN 55455 USANicole Rendine - Drexel UniversityBrian Wigdahl - Drexel UniversityFred C. Krebs - Drexel UniversityPeter J. Bruggeman - Univ Minnesota, Dept Mech Engn, Coll Sci & Engn, 111 Church St SE, Minneapolis, MN 55455 USAVandana Miller - Drexel UniversityUniv. of Minnesota, Minneapolis, MN (United States)
- Publication Details
- Frontiers in physics, v 9
- Publisher
- Frontiers Media Sa
- Number of pages
- 25
- Grant note
- Coulter Foundation DE-SC0016053 / Department of Energy, Office of Fusion Energy Science; United States Department of Energy (DOE) PHY 2020695 / National Science Foundation; National Science Foundation (NSF) Institute for Molecular Medicine and Infectious Disease at the Drexel University College of Medicine Department of Microbiology and Immunology at the Drexel University College of Medicine
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000661540000001
- Scopus ID
- 2-s2.0-85107969313
- Other Identifier
- 991019168303804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Physics, Multidisciplinary